Matches in SemOpenAlex for { <https://semopenalex.org/work/W1612601009> ?p ?o ?g. }
- W1612601009 abstract "In the last two years, clinical trials with blocking antibodies to the negative checkpoint regulators CTLA-4 and PD-1 have rekindled the hope for cancer immunotherapy. Multiple negative checkpoint regulators protect the host against autoimmune reactions but also restrict the ability of T cells to effectively attack tumors. Releasing these brakes has emerged as an exciting strategy for cancer treatment. Conversely, these pathways can be manipulated to achieve durable tolerance for treatment of autoimmune diseases and transplantation. In the future, treatment may involve combination therapy to target multiple cell types and stages of the adaptive immune responses. In this review, we describe the current knowledge on the recently discovered negative checkpoint regulators, future targets for immunotherapy." @default.
- W1612601009 created "2016-06-24" @default.
- W1612601009 creator A5010521347 @default.
- W1612601009 creator A5018407875 @default.
- W1612601009 creator A5050616725 @default.
- W1612601009 date "2015-08-21" @default.
- W1612601009 modified "2023-10-06" @default.
- W1612601009 title "Beyond CTLA-4 and PD-1, the Generation Z of Negative Checkpoint Regulators" @default.
- W1612601009 cites W1480698358 @default.
- W1612601009 cites W1481317976 @default.
- W1612601009 cites W1485845931 @default.
- W1612601009 cites W1500123828 @default.
- W1612601009 cites W1523413731 @default.
- W1612601009 cites W1534000773 @default.
- W1612601009 cites W1572739876 @default.
- W1612601009 cites W1593046582 @default.
- W1612601009 cites W1606078320 @default.
- W1612601009 cites W1606763503 @default.
- W1612601009 cites W1613752608 @default.
- W1612601009 cites W1643523773 @default.
- W1612601009 cites W1660059067 @default.
- W1612601009 cites W1678412754 @default.
- W1612601009 cites W1824529173 @default.
- W1612601009 cites W1841418760 @default.
- W1612601009 cites W1850631646 @default.
- W1612601009 cites W1856206988 @default.
- W1612601009 cites W1858140195 @default.
- W1612601009 cites W1899061528 @default.
- W1612601009 cites W1900161907 @default.
- W1612601009 cites W1905064515 @default.
- W1612601009 cites W1915191412 @default.
- W1612601009 cites W1932046647 @default.
- W1612601009 cites W1937813437 @default.
- W1612601009 cites W1954997335 @default.
- W1612601009 cites W1967926393 @default.
- W1612601009 cites W1968113197 @default.
- W1612601009 cites W1968524415 @default.
- W1612601009 cites W1971425687 @default.
- W1612601009 cites W1972073222 @default.
- W1612601009 cites W1972338421 @default.
- W1612601009 cites W1975934877 @default.
- W1612601009 cites W1976105607 @default.
- W1612601009 cites W1978715924 @default.
- W1612601009 cites W1980897648 @default.
- W1612601009 cites W1983744239 @default.
- W1612601009 cites W1983812780 @default.
- W1612601009 cites W1984370347 @default.
- W1612601009 cites W1985117788 @default.
- W1612601009 cites W1985997449 @default.
- W1612601009 cites W1986533011 @default.
- W1612601009 cites W1987004269 @default.
- W1612601009 cites W1988474688 @default.
- W1612601009 cites W1990718425 @default.
- W1612601009 cites W1990826761 @default.
- W1612601009 cites W1990951542 @default.
- W1612601009 cites W1991807494 @default.
- W1612601009 cites W1992249154 @default.
- W1612601009 cites W1994257755 @default.
- W1612601009 cites W1996717063 @default.
- W1612601009 cites W1997731331 @default.
- W1612601009 cites W1999623709 @default.
- W1612601009 cites W2002516194 @default.
- W1612601009 cites W2006187748 @default.
- W1612601009 cites W2013177587 @default.
- W1612601009 cites W2018161209 @default.
- W1612601009 cites W2020090293 @default.
- W1612601009 cites W2020450604 @default.
- W1612601009 cites W2020898162 @default.
- W1612601009 cites W2021379322 @default.
- W1612601009 cites W2022216088 @default.
- W1612601009 cites W2023283620 @default.
- W1612601009 cites W2026236493 @default.
- W1612601009 cites W2027673321 @default.
- W1612601009 cites W2029399624 @default.
- W1612601009 cites W2030995912 @default.
- W1612601009 cites W2031627869 @default.
- W1612601009 cites W2031764503 @default.
- W1612601009 cites W2034554545 @default.
- W1612601009 cites W2035759292 @default.
- W1612601009 cites W2035808799 @default.
- W1612601009 cites W2038064001 @default.
- W1612601009 cites W2041143310 @default.
- W1612601009 cites W2043019041 @default.
- W1612601009 cites W2045570438 @default.
- W1612601009 cites W2046409157 @default.
- W1612601009 cites W2050457398 @default.
- W1612601009 cites W2052855154 @default.
- W1612601009 cites W2054698310 @default.
- W1612601009 cites W2056211666 @default.
- W1612601009 cites W2058380315 @default.
- W1612601009 cites W2064360402 @default.
- W1612601009 cites W2068047393 @default.
- W1612601009 cites W2068286936 @default.
- W1612601009 cites W2070631889 @default.
- W1612601009 cites W2070873336 @default.
- W1612601009 cites W2071782041 @default.
- W1612601009 cites W2073303594 @default.
- W1612601009 cites W2076248543 @default.
- W1612601009 cites W2076846857 @default.
- W1612601009 cites W2081118119 @default.