FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1612653354> ?p ?o ?g. }

• W1612653354 endingPage "1317" @default.
• W1612653354 startingPage "1307" @default.
• W1612653354 abstract "Abstract Previously, we demonstrated that spontaneous TNF-α production by macrophages in rheumatoid arthritis (RA) synovial tissue is largely driven by contact-dependent activation with T cells in that tissue. Whereas abundant IL-10 is present in these RA synovial cultures, it does not adequately control the production of TNF-α. In this study, we have compared the mechanisms involved in IL-10–mediated TNF-α regulation in LPS-stimulated macrophages with macrophages stimulated with activated T cells. We confirm that in LPS-stimulated macrophages the 3′ enhancer region of tnf is essential for tnf transcription, and its regulation by IL-10 is dominated by a STAT3-dependent pathway. However, in contrast, we have found that tnf transcription in macrophages stimulated by activated T cells or by RA synovial T cells does not require the 3′ enhancer region of tnf, and that its regulation by IL-10 is subsequently altered and clearly is not mediated by a dominant STAT3 pathway. These observations have very important implications for our understanding as to how IL-10 regulates TNF-α production at sites of chronic inflammation, such as the synovial tissue of patients with RA. Furthermore, these distinct IL-10 mechanisms will have bearing upon the identification of potential therapeutic targets in RA synovial macrophages where the activation stimulus is clearly not LPS." @default.
• W1612653354 created "2016-06-24" @default.
• W1612653354 creator A5018434601 @default.
• W1612653354 creator A5065872194 @default.
• W1612653354 creator A5076724733 @default.
• W1612653354 creator A5077042688 @default.
• W1612653354 creator A5079345390 @default.
• W1612653354 creator A5089425681 @default.
• W1612653354 date "2012-02-01" @default.
• W1612653354 modified "2023-10-16" @default.
• W1612653354 title "Production of TNF-α in Macrophages Activated by T Cells, Compared with Lipopolysaccharide, Uses Distinct IL-10–Dependent Regulatory Mechanism" @default.
• W1612653354 cites W1749220020 @default.
• W1612653354 cites W1954030774 @default.
• W1612653354 cites W1964982794 @default.
• W1612653354 cites W1965869178 @default.
• W1612653354 cites W1966855094 @default.
• W1612653354 cites W1973748965 @default.
• W1612653354 cites W1982664065 @default.
• W1612653354 cites W1996472975 @default.
• W1612653354 cites W2025853481 @default.
• W1612653354 cites W2032530940 @default.
• W1612653354 cites W2036455715 @default.
• W1612653354 cites W2039499980 @default.
• W1612653354 cites W2042136358 @default.
• W1612653354 cites W2043287930 @default.
• W1612653354 cites W2056813079 @default.
• W1612653354 cites W2070288997 @default.
• W1612653354 cites W2078513879 @default.
• W1612653354 cites W2093117857 @default.
• W1612653354 cites W2107350019 @default.
• W1612653354 cites W2127303484 @default.
• W1612653354 cites W2135735584 @default.
• W1612653354 cites W2141077451 @default.
• W1612653354 cites W2142273705 @default.
• W1612653354 cites W2143939606 @default.
• W1612653354 cites W2161854417 @default.
• W1612653354 cites W2169153746 @default.
• W1612653354 cites W2169873489 @default.
• W1612653354 cites W2191654227 @default.
• W1612653354 cites W2328587823 @default.
• W1612653354 doi "https://doi.org/10.4049/jimmunol.1100625" @default.
• W1612653354 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22219323" @default.
• W1612653354 hasPublicationYear "2012" @default.
• W1612653354 type Work @default.
• W1612653354 sameAs 1612653354 @default.
• W1612653354 citedByCount "27" @default.
• W1612653354 countsByYear W16126533542013 @default.
• W1612653354 countsByYear W16126533542014 @default.
• W1612653354 countsByYear W16126533542015 @default.
• W1612653354 countsByYear W16126533542016 @default.
• W1612653354 countsByYear W16126533542017 @default.
• W1612653354 countsByYear W16126533542018 @default.
• W1612653354 countsByYear W16126533542019 @default.
• W1612653354 countsByYear W16126533542020 @default.
• W1612653354 countsByYear W16126533542021 @default.
• W1612653354 countsByYear W16126533542022 @default.
• W1612653354 countsByYear W16126533542023 @default.
• W1612653354 crossrefType "journal-article" @default.
• W1612653354 hasAuthorship W1612653354A5018434601 @default.
• W1612653354 hasAuthorship W1612653354A5065872194 @default.
• W1612653354 hasAuthorship W1612653354A5076724733 @default.
• W1612653354 hasAuthorship W1612653354A5077042688 @default.
• W1612653354 hasAuthorship W1612653354A5079345390 @default.
• W1612653354 hasAuthorship W1612653354A5089425681 @default.
• W1612653354 hasBestOaLocation W16126533541 @default.
• W1612653354 hasConcept C17991360 @default.
• W1612653354 hasConcept C185592680 @default.
• W1612653354 hasConcept C187316574 @default.
• W1612653354 hasConcept C203014093 @default.
• W1612653354 hasConcept C2776914184 @default.
• W1612653354 hasConcept C2777652487 @default.
• W1612653354 hasConcept C2778690821 @default.
• W1612653354 hasConcept C2778754761 @default.
• W1612653354 hasConcept C86803240 @default.
• W1612653354 hasConcept C95444343 @default.
• W1612653354 hasConceptScore W1612653354C17991360 @default.
• W1612653354 hasConceptScore W1612653354C185592680 @default.
• W1612653354 hasConceptScore W1612653354C187316574 @default.
• W1612653354 hasConceptScore W1612653354C203014093 @default.
• W1612653354 hasConceptScore W1612653354C2776914184 @default.
• W1612653354 hasConceptScore W1612653354C2777652487 @default.
• W1612653354 hasConceptScore W1612653354C2778690821 @default.
• W1612653354 hasConceptScore W1612653354C2778754761 @default.
• W1612653354 hasConceptScore W1612653354C86803240 @default.
• W1612653354 hasConceptScore W1612653354C95444343 @default.
• W1612653354 hasIssue "3" @default.
• W1612653354 hasLocation W16126533541 @default.
• W1612653354 hasLocation W16126533542 @default.
• W1612653354 hasOpenAccess W1612653354 @default.
• W1612653354 hasPrimaryLocation W16126533541 @default.
• W1612653354 hasRelatedWork W2004283601 @default.
• W1612653354 hasRelatedWork W2062553756 @default.
• W1612653354 hasRelatedWork W2065223339 @default.
• W1612653354 hasRelatedWork W2068805684 @default.
• W1612653354 hasRelatedWork W2107907376 @default.
• W1612653354 hasRelatedWork W2119906870 @default.
• W1612653354 hasRelatedWork W2123116789 @default.
• W1612653354 hasRelatedWork W2162110762 @default.

• next