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• W1613302221 abstract "Summary l ‐asparaginase encapsulated within erythrocytes (GRASPA ® ) should allow serum asparagine depletion over a longer period than the native form of the enzyme, using lower doses and allowing better tolerance. The GRASPALL 2005‐01 study, a multicentre randomized controlled trial, investigated three doses of GRASPA ® for the duration of asparagine depletion in a phase I/II study in adults and children with acute lymphoblastic leukaemia (ALL) in first relapse. Between February 2006 and April 2008, 18 patients received GRASPA ® (50 iu/kg: n = 6, 100 iu/kg: n = 6, 150 iu/kg: n = 6) after randomization, and six patients were assigned to the Escherichia coli native l ‐asparaginase ( E. coli l ‐ASNase) control group. GRASPA ® was effective at depleting l ‐asparagine. One single injection of 150 iu/kg of GRASPA ® provided similar results to 8 × 10 000 iu/m 2 intravenous injections of E. coli l ‐ASNase. The safety profile of GRASPA ® showed a reduction in the number and severity of allergic reactions and a trend towards less coagulation disorders. Other expected adverse events were comparable to those observed with E. coli l ‐ASNase and there was also no difference between the three doses of GRASPA ® ." @default.
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• W1613302221 date "2011-02-20" @default.
• W1613302221 modified "2023-10-18" @default.
• W1613302221 title "l-asparaginase loaded red blood cells in refractory or relapsing acute lymphoblastic leukaemia in children and adults: results of the GRASPALL 2005-01 randomized trial" @default.
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• W1613302221 doi "https://doi.org/10.1111/j.1365-2141.2011.08588.x" @default.
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