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- W161330331 abstract "BackgroundDiaSens is an optical sensor that uses UV-light to measure the rate of substances removal from the blood during dialysis thus being able to monitor the dialysis quality. DiaSens is connected to the drain output of the dialysis machine with dialysate passing through its flow-through optical cell. The concentration of substances in spent dialysate is directly proportional to the light absorbance. The sensor working principle is based on Beer-Lambert’s law.ObjectiveEvaluate DiaSens measurement results in comparison with blood urea measurements.MethodsThe study included 19 treatments in total from 5 uremic patients, both male and female. All patients were on chronic thrice-weekly haemodialysis therapy and standard procedure duration varied from 180 to 300 minutes. Study included both stable and unstable treatments.ResultsThe mean values of the estimated parameters (mean ± SD) were: (1) Kt/V was 1,07 ± 0,14, (N = 11), spKt/V was 1,13 ± 0,20, (N = 11), and eKt/V was 1,07 ± 0,12, (N = 11) from DiaSens, and (2) Kt/V was 1,15 ± 0,15, (N = 11), spKt/V was 1,20 ± 0,14, (N = 11), and eKt/V was 1,14 ± 0,14, (N = 11) from the blood sample analysis. Difference between the Kt/V, spKt/V and eKt/V obtained from the blood sample analysis and DiaSens was approximately 10% from the corresponding DiaSens average absolute values being stably 0.07 lower comparing to the blood urea tests.ConclusionThe measurement results obtained by DiaSens have a strong and stable relationship with those received using the reference laboratory technique. DiaSens could be used in hospitals for routine dialysis adequacy monitoring to complement or replace blood sampling method.KeywordsDiaSensoptical dialysis monitoringKt/Vdialysis qualitydialysis adequacy" @default.
- W161330331 created "2016-06-24" @default.
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- W161330331 date "2008-01-01" @default.
- W161330331 modified "2023-10-14" @default.
- W161330331 title "Dialysis Adequacy On-line Monitoring Using DiaSens Optical Sensor: Technique and Clinical Application" @default.
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- W161330331 doi "https://doi.org/10.1007/978-3-540-69367-3_86" @default.
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