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- W161363673 abstract "Cells seldom live in isolation. They constantly interact with ambient cells and the environment. Many conventional studies have focused on particular molecular activities taking place within cells, which are cultured in artificial environments, so the rich interaction between the cells and their natural environment is unexplored. To acquire a more complete picture, systematic investigation of all cellular activities in different environmental settings would be valuable. With three distinct omics (genomics, transcriptomics and proteomics), we will see how new insights into human biology can be approached by systematic hypothesis generation and panoramic, multi-scale data filtering, integration and modeling. Systems biomedical science is an iteration of bottom-up and top-down investigations. Individual systems are simulated jointly for their emergent collective behavior. Case studies include whole cell modeling, synchronization and phase locking models of cell cycles, essential genes for the normal operation of cell cycles, and the hourglass model for embryonic development in many species." @default.
- W161363673 created "2016-06-24" @default.
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- W161363673 date "2013-01-01" @default.
- W161363673 modified "2023-10-06" @default.
- W161363673 title "Systems biomedical science" @default.
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- W161363673 doi "https://doi.org/10.1533/9781908818232.107" @default.
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