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- W1613816674 abstract "Background: Asthma in obese subjects is poorly understood and is described as a specific phenotype. Literature suggests neutrophilic airway inflammation in these patients in contrast to the classic eosinophilic inflammation. Aim: To investigate the nature of bronchial inflammation in obese asthma patients. Methods: This is a cross-sectional study in obese patients with confirmed diagnosis of asthma (GINA guidelines) and non asthmatic patients undergoing bariatric surgery. In central bronchial biopsies taken during bariatric surgery, eosinophils, neutrophils and mast cells in submucosa were analysed. Results: 29 obese asthmatics and 47 obese non-asthmatics were included. The groups did not differ in gender, age, BMI, abdominal circumference or smoking history. Asthma subjects had a significant lower FEV 1 , ACQ and methacholine PD20 than controls (87 vs 98%pred, p Conclusions: This is the first study were bronchial biopsies are performed in morbidly obese asthma patients, showing that asthma is not characterized by increased number of either eosinophils, neutrophils or mast cells in bronchial mucosa. These findings suggest that airway inflammation is not a major contributor to the development of asthma in the morbidly obese." @default.
- W1613816674 created "2016-06-24" @default.
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- W1613816674 date "2013-09-01" @default.
- W1613816674 modified "2023-09-28" @default.
- W1613816674 title "Mucosal inflammation in bronchial biopsies of morbidly obese asthma subjects" @default.
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