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- W1614025747 abstract "Pills and capsules may release their contents within minutes of ingestion; these are immediate-release formulations. Pills and capsules may also release their contents after a time lag, or a little at a time, or in some other predetermined way; these are time-release formulations. Many drugs in psychiatry have been time-release formulated to reduce their local adverse effects in the gastrointestinal tract, to reduce adverse effects associated with peak blood levels, or to artificially extend their half-life. Time-release formulations are associated with the added advantages of convenience of dosing, improved compliance, and less fluctuation in blood levels across the course of the day. A disadvantage of time-release formulations is that they may be incompletely absorbed; this is a serious issue in patients with acute or chronic intestinal hurry disorders, such as gastroenteritis or irritable bowel syndrome. Time-release formulations may also be more expensive than immediate-release formulations." @default.
- W1614025747 created "2016-06-24" @default.
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- W1614025747 date "2015-08-26" @default.
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- W1614025747 title "Sustained-Release, Extended-Release, and Other Time-Release Formulations in Neuropsychiatry" @default.
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- W1614025747 doi "https://doi.org/10.4088/jcp.15f10219" @default.
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