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- W1614187985 abstract "Summary A lipide emulsion of 7,12-dimethylbenz[ a ]anthracene (7,12-DMBA) was prepared which has the advantages of a high concentration of the hydrocarbon, ease of preparation, sterility, and stability. The vehicle was not toxic. A single intraperitoneal injection of the emulsion of 7,12-DMBA induced mammary cancer preferentially in all Sprague-Dawley female rats, age 50 days, within 2 months. In the induction of mammary tumors, the emulsion was quantitatively as effective by the intraperitoneal as by the intravenous route. No tumors of peritoneum were evoked by a single injection of the emulsified 7,12-DMBA, but peritoneal sarcomas arose in a high incidence following deposition of a compressed pellet of 7,12-DMBA in the peritoneal cavity. A single, intraperitoneal injection of the emulsion of 7,12-DMBA in new born female rats of Sprague-Dawley or Long-Evans strains evoked mammary tumors in high incidence. Benign mammary tumors developed in high and equal incidence in both strains following the injection of 7,12-DMBA, but the incidence of mammary cancer was rather high in Sprague-Dawley rats and very low in their Long-Evans companions. Runt disease was induced in some of the injected newborn rats." @default.
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- W1614187985 date "1963-06-01" @default.
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- W1614187985 title "Mammary and Peritoneal Tumors Induced by Intraperitoneal Administration of 7,12-Dimethylbenz[a]anthracene in Newborn and Adult Rats" @default.
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