FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1614749602> ?p ?o ?g. }

• W1614749602 endingPage "2936" @default.
• W1614749602 startingPage "2931" @default.
• W1614749602 abstract "Abstract Previous reports that diabetogenic lymphocytes did not induce diabetes in nonobese diabetic (NOD)-lpr mice suggested the critical role of Fas-Fas ligand (FasL) interaction in pancreatic β cell apoptosis. However, recent works demonstrated that FasL is not an effector molecule in islet β cell death. We addressed why diabetes cannot be transferred to NOD-lpr mice despite the nonessential role of Fas in β cell apoptosis. Lymphocytes from NOD-lpr mice were constitutively expressing FasL. A decrease in the number of FasL+ lymphocytes by neonatal thymectomy facilitated the development of insulitis. Cotransfer of FasL+ lymphocytes from NOD-lpr mice completely abrogated diabetes after adoptive transfer of lymphocytes from diabetic NOD mice. The inhibition of diabetes by cotransferred lymphocytes was reversed by anti-FasL Ab, indicating that FasL on abnormal lymphocytes from NOD-lpr mice was responsible for the inhibition of diabetes transfer. Pretreatment of lymphocytes with soluble FasL (sFasL) also inhibited diabetes transfer. sFasL treatment decreased the number of CD4+CD45RBlow cells and increased the number of propidium iodide-stained cells among CD4+CD45RBlow cells, suggesting that sFasL induces apoptosis on CD4+CD45RBlow “memory” cells. These results resolve the paradox between previous findings and suggest a new role for FasL in the treatment of autoimmune disorders. Our data also suggest that sFasL is involved in the deletion of potentially hazardous peripheral “memory” cells, contrary to previous reports that Fas on unmanipulated peripheral lymphocytes is nonfunctional." @default.
• W1614749602 created "2016-06-24" @default.
• W1614749602 creator A5014594900 @default.
• W1614749602 creator A5015481616 @default.
• W1614749602 creator A5019242817 @default.
• W1614749602 creator A5046332347 @default.
• W1614749602 creator A5060850021 @default.
• W1614749602 creator A5070494006 @default.
• W1614749602 creator A5072359871 @default.
• W1614749602 date "2000-03-15" @default.
• W1614749602 modified "2023-10-16" @default.
• W1614749602 title "Inhibition of Autoimmune Diabetes by Fas Ligand: The Paradox Is Solved" @default.
• W1614749602 cites W1496938524 @default.
• W1614749602 cites W1517945724 @default.
• W1614749602 cites W1534110338 @default.
• W1614749602 cites W1539984014 @default.
• W1614749602 cites W1558865081 @default.
• W1614749602 cites W1561515054 @default.
• W1614749602 cites W1603128511 @default.
• W1614749602 cites W1832021939 @default.
• W1614749602 cites W1966426964 @default.
• W1614749602 cites W1967704552 @default.
• W1614749602 cites W1970921166 @default.
• W1614749602 cites W2003285575 @default.
• W1614749602 cites W2005214142 @default.
• W1614749602 cites W2010645451 @default.
• W1614749602 cites W2033270059 @default.
• W1614749602 cites W2037804577 @default.
• W1614749602 cites W2047125790 @default.
• W1614749602 cites W2052620999 @default.
• W1614749602 cites W2057465787 @default.
• W1614749602 cites W2067534266 @default.
• W1614749602 cites W2072730971 @default.
• W1614749602 cites W2093913291 @default.
• W1614749602 cites W2097499121 @default.
• W1614749602 cites W2098809648 @default.
• W1614749602 cites W2114829069 @default.
• W1614749602 cites W2122401031 @default.
• W1614749602 cites W2128851263 @default.
• W1614749602 cites W2132532171 @default.
• W1614749602 cites W2136536421 @default.
• W1614749602 cites W2137694849 @default.
• W1614749602 cites W2143996326 @default.
• W1614749602 cites W2168945225 @default.
• W1614749602 cites W318895879 @default.
• W1614749602 cites W4234845870 @default.
• W1614749602 cites W4242609848 @default.
• W1614749602 doi "https://doi.org/10.4049/jimmunol.164.6.2931" @default.
• W1614749602 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10706679" @default.
• W1614749602 hasPublicationYear "2000" @default.
• W1614749602 type Work @default.
• W1614749602 sameAs 1614749602 @default.
• W1614749602 citedByCount "79" @default.
• W1614749602 countsByYear W16147496022012 @default.
• W1614749602 countsByYear W16147496022013 @default.
• W1614749602 countsByYear W16147496022015 @default.
• W1614749602 countsByYear W16147496022016 @default.
• W1614749602 countsByYear W16147496022017 @default.
• W1614749602 countsByYear W16147496022019 @default.
• W1614749602 countsByYear W16147496022020 @default.
• W1614749602 countsByYear W16147496022023 @default.
• W1614749602 crossrefType "journal-article" @default.
• W1614749602 hasAuthorship W1614749602A5014594900 @default.
• W1614749602 hasAuthorship W1614749602A5015481616 @default.
• W1614749602 hasAuthorship W1614749602A5019242817 @default.
• W1614749602 hasAuthorship W1614749602A5046332347 @default.
• W1614749602 hasAuthorship W1614749602A5060850021 @default.
• W1614749602 hasAuthorship W1614749602A5070494006 @default.
• W1614749602 hasAuthorship W1614749602A5072359871 @default.
• W1614749602 hasBestOaLocation W16147496021 @default.
• W1614749602 hasConcept C134018914 @default.
• W1614749602 hasConcept C190283241 @default.
• W1614749602 hasConcept C203014093 @default.
• W1614749602 hasConcept C2776090121 @default.
• W1614749602 hasConcept C2778013207 @default.
• W1614749602 hasConcept C2779511750 @default.
• W1614749602 hasConcept C2780130043 @default.
• W1614749602 hasConcept C31573885 @default.
• W1614749602 hasConcept C55493867 @default.
• W1614749602 hasConcept C555293320 @default.
• W1614749602 hasConcept C55851684 @default.
• W1614749602 hasConcept C66008609 @default.
• W1614749602 hasConcept C86803240 @default.
• W1614749602 hasConcept C8891405 @default.
• W1614749602 hasConcept C90375314 @default.
• W1614749602 hasConceptScore W1614749602C134018914 @default.
• W1614749602 hasConceptScore W1614749602C190283241 @default.
• W1614749602 hasConceptScore W1614749602C203014093 @default.
• W1614749602 hasConceptScore W1614749602C2776090121 @default.
• W1614749602 hasConceptScore W1614749602C2778013207 @default.
• W1614749602 hasConceptScore W1614749602C2779511750 @default.
• W1614749602 hasConceptScore W1614749602C2780130043 @default.
• W1614749602 hasConceptScore W1614749602C31573885 @default.
• W1614749602 hasConceptScore W1614749602C55493867 @default.
• W1614749602 hasConceptScore W1614749602C555293320 @default.
• W1614749602 hasConceptScore W1614749602C55851684 @default.
• W1614749602 hasConceptScore W1614749602C66008609 @default.
• W1614749602 hasConceptScore W1614749602C86803240 @default.

• next