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- W161482875 abstract "When noradrenaline (NA) (10 μM) and acetylcholine (ACh) (1 μM) were applied simultaneously to the isolated rabbit sinoatrial (S-A) node, increase in levels of cyclic guanosine 3′:5′-monophosphate (cyclic GMP) was in good agreement with the decreased pacemaker rate. A gradual, time-dependent increase in cyclic adenosine 3′:5′-monophosphate (cyclic AMP) level associated with increase in the rate was observed. Pretreatment with atropine (1 μM) shortened the time required to attain a maximum increase in cyclic AMP after simultaneous application of ACh and NA. These results suggest that the delayed effect of NA on chronotropism is due to a rapid increase in cyclic GMP level which suppresses the NA-induced elevation of cyclic AMP." @default.
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- W161482875 date "1979-01-01" @default.
- W161482875 modified "2023-09-27" @default.
- W161482875 title "CONTRIBUTION OF CYCLIC AMP IN THE DELAYED EFFECT OF NORADRENALINE ON CHRONOTROPISM OF SINOATRIAL NODE WITH SIMULTANEOUS APPLICATION OF NORADRENALINE AND ACETYLCHOLINE" @default.
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- W161482875 doi "https://doi.org/10.1016/b978-1-4832-8363-0.50132-4" @default.
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