Matches in SemOpenAlex for { <https://semopenalex.org/work/W1614919614> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W1614919614 endingPage "101" @default.
- W1614919614 startingPage "91" @default.
- W1614919614 abstract "Objectives: In this study, we investigated the inhibitory effects of Ampelopsis Radix methanol(AR-M) extract on allergic inflammation in activated human mast cells and its potential therapeutic or toxic effects. Methods: Ampelopsis Radix(AR) was extracted with 80% methanol. HMC-1 cells, a human mast cell line, were treated with different concentrations of AR-M extract, and then stimulated with PMA plus A23187. The cell toxicity of AR-M extract was determined by MTT assay. The concentrations of and cytokines were measured by ELISA. The gene expression of COX-2 and its protein levels were determined by RT-PCR and Western blot. The phosphorylation of ERK MAPK and the NF- activation were determined by Western blot. Results: AR-M extract was significantly inhibited the production of PGE2 and inflammatory cytokines(TNF-, IL-6 and IL-8) in PMA/A23187-stimulated HMC-1 cells. AR-M extract also attenuated the mRNA expression of COX-2 and its protein induction. Furthermore, AR-M extract attenuated PMA/A23187-induced phophorylation of ERK1/2 MAPK and the NF- p65 subunit translocation into nuclear of HMC-1 cells. AR-M extract significantly decreased PMN A23187-induced release of histamine in a dose-dependent manner. Conclusions: These results indicate that Ampelopsis Radix shows the property of anti-allergic inflammation In vitro through suppressing the production of inflammatory mediators released from mast cells, suggesting have a potential for the treatment of allergic diseases." @default.
- W1614919614 created "2016-06-24" @default.
- W1614919614 creator A5002184891 @default.
- W1614919614 creator A5018228594 @default.
- W1614919614 creator A5043237522 @default.
- W1614919614 creator A5062797851 @default.
- W1614919614 date "2008-01-01" @default.
- W1614919614 modified "2023-09-24" @default.
- W1614919614 title "The Effects of Ampelopsis Radix on Allergic Inflammation in PMA-stimulated Human Mast Cells" @default.
- W1614919614 cites W2054172795 @default.
- W1614919614 cites W2168907731 @default.
- W1614919614 hasPublicationYear "2008" @default.
- W1614919614 type Work @default.
- W1614919614 sameAs 1614919614 @default.
- W1614919614 citedByCount "0" @default.
- W1614919614 crossrefType "journal-article" @default.
- W1614919614 hasAuthorship W1614919614A5002184891 @default.
- W1614919614 hasAuthorship W1614919614A5018228594 @default.
- W1614919614 hasAuthorship W1614919614A5043237522 @default.
- W1614919614 hasAuthorship W1614919614A5062797851 @default.
- W1614919614 hasConcept C104317684 @default.
- W1614919614 hasConcept C1122143 @default.
- W1614919614 hasConcept C153911025 @default.
- W1614919614 hasConcept C184235292 @default.
- W1614919614 hasConcept C185592680 @default.
- W1614919614 hasConcept C202751555 @default.
- W1614919614 hasConcept C203014093 @default.
- W1614919614 hasConcept C2776415932 @default.
- W1614919614 hasConcept C2776914184 @default.
- W1614919614 hasConcept C2779726688 @default.
- W1614919614 hasConcept C2780783641 @default.
- W1614919614 hasConcept C55493867 @default.
- W1614919614 hasConcept C57074206 @default.
- W1614919614 hasConcept C86803240 @default.
- W1614919614 hasConcept C98274493 @default.
- W1614919614 hasConceptScore W1614919614C104317684 @default.
- W1614919614 hasConceptScore W1614919614C1122143 @default.
- W1614919614 hasConceptScore W1614919614C153911025 @default.
- W1614919614 hasConceptScore W1614919614C184235292 @default.
- W1614919614 hasConceptScore W1614919614C185592680 @default.
- W1614919614 hasConceptScore W1614919614C202751555 @default.
- W1614919614 hasConceptScore W1614919614C203014093 @default.
- W1614919614 hasConceptScore W1614919614C2776415932 @default.
- W1614919614 hasConceptScore W1614919614C2776914184 @default.
- W1614919614 hasConceptScore W1614919614C2779726688 @default.
- W1614919614 hasConceptScore W1614919614C2780783641 @default.
- W1614919614 hasConceptScore W1614919614C55493867 @default.
- W1614919614 hasConceptScore W1614919614C57074206 @default.
- W1614919614 hasConceptScore W1614919614C86803240 @default.
- W1614919614 hasConceptScore W1614919614C98274493 @default.
- W1614919614 hasIssue "4" @default.
- W1614919614 hasLocation W16149196141 @default.
- W1614919614 hasOpenAccess W1614919614 @default.
- W1614919614 hasPrimaryLocation W16149196141 @default.
- W1614919614 hasRelatedWork W138799763 @default.
- W1614919614 hasRelatedWork W1932790382 @default.
- W1614919614 hasRelatedWork W1965846477 @default.
- W1614919614 hasRelatedWork W1974000328 @default.
- W1614919614 hasRelatedWork W1986099180 @default.
- W1614919614 hasRelatedWork W2049885048 @default.
- W1614919614 hasRelatedWork W2156222682 @default.
- W1614919614 hasRelatedWork W2321391215 @default.
- W1614919614 hasRelatedWork W2579315390 @default.
- W1614919614 hasRelatedWork W2594618457 @default.
- W1614919614 hasRelatedWork W2624647150 @default.
- W1614919614 hasRelatedWork W2748213309 @default.
- W1614919614 hasRelatedWork W2808801488 @default.
- W1614919614 hasRelatedWork W2899224043 @default.
- W1614919614 hasRelatedWork W2900646504 @default.
- W1614919614 hasRelatedWork W3006270644 @default.
- W1614919614 hasRelatedWork W3110739685 @default.
- W1614919614 hasRelatedWork W3135103353 @default.
- W1614919614 hasRelatedWork W3204224669 @default.
- W1614919614 hasRelatedWork W3214419173 @default.
- W1614919614 hasVolume "23" @default.
- W1614919614 isParatext "false" @default.
- W1614919614 isRetracted "false" @default.
- W1614919614 magId "1614919614" @default.
- W1614919614 workType "article" @default.