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• W1614945897 startingPage "2039" @default.
• W1614945897 abstract "The purpose of this study was to determine whether increases in adenosine monophosphate (AMP) deaminase activity in precancerous rat liver were correlated with proliferation among hepatic parenchymal cells. Rats were fed thioacetamide or the 3′-methyl- (3′-Me), 4′-methyl- (4′-Me), and 4′-fluoro- (4′-F) derivatives of 4-dimethylaminoazobenzene (DAB). Proliferation among hepatic parenchymal cells was assessed by 2 criteria: DNA synthesis determined autoradiographically or inhibition of cortisone induction of tryptophan oxygenase (E.C.1.13.1.12). Thioacetamide, 3′-Me-DAB, and 4′-F-DAB increased hepatocyte DNA synthesis, inhibited cortisone induction of tryptophan oxygenase, and stimulated hepatic AMP deaminase activity; 4′-Me-DAB did not alter any of these. 4′-F-DAB, when fed in a diet containing moderate riboflavin levels, was not hepatocarcinogenic and did not stimulate hepatocyte DNA synthesis or hepatic AMP deaminase activity. Injection of 3′-Me-DAB or thioacetamide also stimulated hepatocyte DNA synthesis, inhibited tryptophan oxygenase induction, and stimulated AMP deaminase activity. Simultaneous administration of ethionine with thioacetamide inhibited DNA synthesis.AMP deaminase activity was not stimulated appreciably during liver regeneration, and the modest changes recorded could not be readily attributed to hepatocyte DNA synthesis or mitosis. The relationship between changes in cellularity in precancerous liver and stimulated AMP deaminase activity was discussed." @default.
• W1614945897 created "2016-06-24" @default.
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• W1614945897 date "1969-11-01" @default.
• W1614945897 modified "2023-09-23" @default.
• W1614945897 title "Effect of hepatocarcinogens on hepatocyte DNA synthesis and cortisone induction of tryptophan oxygenase." @default.
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• W1614945897 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4311563" @default.
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