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- W1615442223 abstract "Abstract The migraine prophylactic herb feverfew (Tanacetum parthenium L.) is marketed in the United States in a variety of forms and compositions. Although its therapeutic efficacy is still uncertain, the sesquiterpene lactone parthenolide is the constituent recommended to be measured for quality control of feverfew preparations. A validated liquid chromatographic method was developed and used to estimate parthenolide in a number of U.S. feverfew market products formulated as capsules, tablets, or crude powder. The method uses a Lichrosphere 5 C18 column, a mobile phase consisting of 50mM NaH2PO4 in H2O (solvent A), and CH3CN–MeOH (90 + 10, v/v; solvent B). Elution was run at a flow rate of 1.0 mL/min with a linear gradient of 50–15% A in B over 20 min and UV detection at 210 nm. The correlation coefficient for the calibration curve was 0.9999 over the range of 0.00–0.400 mg/mL. Overall recovery of parthenolide was 103.1%." @default.
- W1615442223 created "2016-06-24" @default.
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- W1615442223 date "2000-07-01" @default.
- W1615442223 modified "2023-09-27" @default.
- W1615442223 title "Determination of Parthenolide in Selected Feverfew Products by Liquid Chromatography" @default.
- W1615442223 doi "https://doi.org/10.1093/jaoac/83.4.789" @default.
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