Matches in SemOpenAlex for { <https://semopenalex.org/work/W1615546978> ?p ?o ?g. }
- W1615546978 endingPage "8465" @default.
- W1615546978 startingPage "8458" @default.
- W1615546978 abstract "Bcl-2 family gene products are critical to the integration of cell death stimuli that target the mitochondrion. Proapoptotic BAD (Bcl-2-associated death protein) has been shown to dissociate from its sequestered site with the molecular chaperone protein 14-3-3 and displace proapoptotic BAX (Bcl-2-associated X protein) from antiapoptotic BCL-Xl. BAX subsequently translocates to the mitochondrion and induces cytochrome <i>c</i> release and caspase activation. Herein we report the response of the key members of this proposed pathway after seizures. Seizures evoked by microinjection of kainic acid into the amygdala of the rat induced unilateral CA3 pyramidal neuron death with features of apoptosis. In control hippocampus and cortex, BAD was found constitutively bound to 14-3-3, whereas BCL-Xl bound BAX. Within damaged hippocampus, seizures induced the dissociation of BAD from 14-3-3 and the subsequent dimerization of BAD with BCL-Xl as determined by immunoprecipitation and immunohistochemical colocalization. 14-3-3 was found to translocate to the nucleus of degenerating neurons, whereas BAX accumulated at mitochondrial membranes. In contrast, the primarily uninjured cortex exhibited increased phosphorylation of Akt (protein kinase B), which may phosphorylate and inhibit BAD, and no altered binding of BAD to BCL-Xl. Finally, administration of an inhibitor of phosphatidylinositol 3-kinase (LY294002), thought to be an upstream activator of Akt, exacerbated cortical apoptosis after seizures. These data suggest that seizures elicit divergent cell death and survival responses within neuronal populations and that the BAD cell death pathway may perform an instigator or reinforcement role in seizure-induced neuronal death." @default.
- W1615546978 created "2016-06-24" @default.
- W1615546978 creator A5011179401 @default.
- W1615546978 creator A5021426572 @default.
- W1615546978 creator A5033556040 @default.
- W1615546978 creator A5044394104 @default.
- W1615546978 creator A5047234832 @default.
- W1615546978 creator A5069808116 @default.
- W1615546978 creator A5080917522 @default.
- W1615546978 date "2002-10-01" @default.
- W1615546978 modified "2023-10-18" @default.
- W1615546978 title "Activation of Bcl-2-Associated Death Protein and Counter-Response of Akt within Cell Populations during Seizure-Induced Neuronal Death" @default.
- W1615546978 cites W1495729285 @default.
- W1615546978 cites W1528505919 @default.
- W1615546978 cites W1535426243 @default.
- W1615546978 cites W1550247880 @default.
- W1615546978 cites W1964617786 @default.
- W1615546978 cites W1965878499 @default.
- W1615546978 cites W1968055572 @default.
- W1615546978 cites W1978559408 @default.
- W1615546978 cites W1979012323 @default.
- W1615546978 cites W1981017578 @default.
- W1615546978 cites W1984547206 @default.
- W1615546978 cites W1988304606 @default.
- W1615546978 cites W2004398763 @default.
- W1615546978 cites W2006242402 @default.
- W1615546978 cites W2007486260 @default.
- W1615546978 cites W2012243761 @default.
- W1615546978 cites W2013137971 @default.
- W1615546978 cites W2015911535 @default.
- W1615546978 cites W2016854943 @default.
- W1615546978 cites W2019836893 @default.
- W1615546978 cites W2020462222 @default.
- W1615546978 cites W2022569128 @default.
- W1615546978 cites W2023462313 @default.
- W1615546978 cites W2024474545 @default.
- W1615546978 cites W2025487647 @default.
- W1615546978 cites W2028526641 @default.
- W1615546978 cites W2029667265 @default.
- W1615546978 cites W2032049833 @default.
- W1615546978 cites W2033801757 @default.
- W1615546978 cites W2035062031 @default.
- W1615546978 cites W2036822121 @default.
- W1615546978 cites W2037302221 @default.
- W1615546978 cites W2038278300 @default.
- W1615546978 cites W2044868069 @default.
- W1615546978 cites W2048121649 @default.
- W1615546978 cites W2048399408 @default.
- W1615546978 cites W2049329312 @default.
- W1615546978 cites W2057713336 @default.
- W1615546978 cites W2058080958 @default.
- W1615546978 cites W2061383116 @default.
- W1615546978 cites W2061810763 @default.
- W1615546978 cites W2062138524 @default.
- W1615546978 cites W2072913100 @default.
- W1615546978 cites W2076314401 @default.
- W1615546978 cites W2077754511 @default.
- W1615546978 cites W2084330376 @default.
- W1615546978 cites W2086667758 @default.
- W1615546978 cites W2088472722 @default.
- W1615546978 cites W2093628776 @default.
- W1615546978 cites W2097767970 @default.
- W1615546978 cites W2106392837 @default.
- W1615546978 cites W2119683782 @default.
- W1615546978 cites W2131644398 @default.
- W1615546978 cites W2131860899 @default.
- W1615546978 cites W2138892400 @default.
- W1615546978 cites W2144701362 @default.
- W1615546978 cites W2313592706 @default.
- W1615546978 doi "https://doi.org/10.1523/jneurosci.22-19-08458.2002" @default.
- W1615546978 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6757765" @default.
- W1615546978 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12351720" @default.
- W1615546978 hasPublicationYear "2002" @default.
- W1615546978 type Work @default.
- W1615546978 sameAs 1615546978 @default.
- W1615546978 citedByCount "192" @default.
- W1615546978 countsByYear W16155469782012 @default.
- W1615546978 countsByYear W16155469782013 @default.
- W1615546978 countsByYear W16155469782014 @default.
- W1615546978 countsByYear W16155469782015 @default.
- W1615546978 countsByYear W16155469782016 @default.
- W1615546978 countsByYear W16155469782017 @default.
- W1615546978 countsByYear W16155469782018 @default.
- W1615546978 countsByYear W16155469782019 @default.
- W1615546978 countsByYear W16155469782020 @default.
- W1615546978 countsByYear W16155469782021 @default.
- W1615546978 countsByYear W16155469782022 @default.
- W1615546978 countsByYear W16155469782023 @default.
- W1615546978 crossrefType "journal-article" @default.
- W1615546978 hasAuthorship W1615546978A5011179401 @default.
- W1615546978 hasAuthorship W1615546978A5021426572 @default.
- W1615546978 hasAuthorship W1615546978A5033556040 @default.
- W1615546978 hasAuthorship W1615546978A5044394104 @default.
- W1615546978 hasAuthorship W1615546978A5047234832 @default.
- W1615546978 hasAuthorship W1615546978A5069808116 @default.
- W1615546978 hasAuthorship W1615546978A5080917522 @default.
- W1615546978 hasBestOaLocation W16155469781 @default.
- W1615546978 hasConcept C11960822 @default.