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- W1615659742 abstract "Abstract Gastrointestinal stromal tumor (GIST), the most common sarcoma arising in the gastrointestinal tract, typically expresses the tyrosine‐kinase receptor, C‐KIT, and contains activating mutation in the c‐kit or platelet‐derived growth factor receptor ( pdgfr ) gene. Recently, development of small molecules that inhibit the kinase activity of mutant C‐KIT and PDGFR proteins has radically changed treatment and prognosis of patients diagnosed with advanced GIST as this molecularly “targeted” therapy has demonstrated remarkable high‐level of activity in this disease. J. Surg. Oncol. 2011; 104:888–895. © 2011 Wiley Periodicals, Inc." @default.
- W1615659742 created "2016-06-24" @default.
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- W1615659742 date "2011-11-08" @default.
- W1615659742 modified "2023-10-16" @default.
- W1615659742 title "Advanced or metastatic gastrointestinal stromal tumors: Systemic treatment options" @default.
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- W1615659742 doi "https://doi.org/10.1002/jso.21930" @default.
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