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- W1615676850 abstract "This chapter focuses on the recent experimental studies that suggest a different role of Epstein–Barr virus (EBV) in the pathogenesis of Burkitt's lymphoma (BL). Particular emphasis is placed on the distinct phenotypic and cytogenetic differences that have been reported to exist between EBV-transformed normal B lymphocytes and BL cells. They show that the in vitro transformation of B cells cannot be regarded as the full equivalent of the malignant transformation of the BL precursor cell in vivo. The chapter also discusses the secondary abnormal progression of lymphoblastoid cells during continuous growth in vitro, including the acquisition of cytogenetic abnormalities, the potential for tumor formation in nude mice, and high clonability in agarose. Finally, the results are examined in relation to the recent seroepidemiological data concerning the relationship of EBV to the development of BL and the specific chromosomal translocations in BL cells. Furthermore, a BL clone develops from B lymphocytes that have acquired preneoplastic characteristics because of EBV transformation and the fully malignant phenotype develops only when the lymphoblastoid cell acquires a specific chromosomal translocation." @default.
- W1615676850 created "2016-06-24" @default.
- W1615676850 creator A5002202838 @default.
- W1615676850 creator A5051391047 @default.
- W1615676850 date "1982-01-01" @default.
- W1615676850 modified "2023-10-09" @default.
- W1615676850 title "Phenotypic and Cytogenetic Characteristics of Human B-Lymphoid Cell Lines and Their Relevance for the Etiology of Burkitt'S Lymphoma" @default.
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