FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1615702087> ?p ?o ?g. }

• W1615702087 endingPage "1196" @default.
• W1615702087 startingPage "1189" @default.
• W1615702087 abstract "Vitamin D has been reported to be reversely associated with type 2 diabetes and metabolic syndrome and is involved in modulation of lipid metabolism. The purpose of the present study was to determine whether 1,25-dihydroxyvitamin D(3) (1,25(OH)(2) D(3) ) has a protective effect on high fat diet (HFD)-induced hepatic steatosis in rats and to elucidate its underlying molecular mechanisms.Male Sprague-Dawley (SD) rats were fed with normal fat diet, HFD or HFD with intraperitoneal injection of 1, 2.5 and 5 μg/kg 1,25(OH)(2) D(3) , respectively, each 2 days for 8 weeks. Serum lipid profile and liver triglyceride were determined. Hepatic histology was examined by haematoxylin/eosin (H&E) and Oil Red O stainings. Hepatic gene expression involved in lipogenesis and lipid oxidation was analysed by quantitative reverse transcription-polymerase chain reaction (RT-PCR).The administration of 1,25(OH)(2) D(3) prevented HFD-induced body weight gain and reduced liver weight. 1,25(OH)(2) D(3) attenuated hepatic steatosis in a dose-dependent manner along with improved serum lipid profile. Furthermore, 1,25(OH)(2) D(3) downregulated mRNA expression of sterol regulatory element binding protein-1c (SREBP-1c) and its target genes acetyl-CoA carboxylase (ACC) and fatty acid synthase (FAS) involved in lipogenesis. Peroxisome proliferator-activated receptor α (PPARα) and its target gene carnitine palmitoyltransferase-1 (CPT-1) involved in hepatic fatty acid (FA) oxidation were upregulated by 1,25(OH)(2) D(3) .These results suggest that the preventing effect of 1,25(OH)(2) D(3) against HFD-induced hepatic steatosis is related to the inhibition of lipogenesis and the promotion of FA oxidation in rat liver." @default.
• W1615702087 created "2016-06-24" @default.
• W1615702087 creator A5021719486 @default.
• W1615702087 creator A5026866614 @default.
• W1615702087 creator A5029876130 @default.
• W1615702087 creator A5032016800 @default.
• W1615702087 creator A5076852689 @default.
• W1615702087 creator A5084685500 @default.
• W1615702087 date "2012-09-08" @default.
• W1615702087 modified "2023-09-30" @default.
• W1615702087 title "Vitamin D attenuates high fat diet-induced hepatic steatosis in rats by modulating lipid metabolism" @default.
• W1615702087 cites W1763406624 @default.
• W1615702087 cites W1786808413 @default.
• W1615702087 cites W1886727246 @default.
• W1615702087 cites W1940094357 @default.
• W1615702087 cites W1966584131 @default.
• W1615702087 cites W1971826130 @default.
• W1615702087 cites W1972561828 @default.
• W1615702087 cites W1988481299 @default.
• W1615702087 cites W1990076402 @default.
• W1615702087 cites W1998143374 @default.
• W1615702087 cites W1998298665 @default.
• W1615702087 cites W2003372762 @default.
• W1615702087 cites W2022186124 @default.
• W1615702087 cites W2032878070 @default.
• W1615702087 cites W2038654926 @default.
• W1615702087 cites W2040109162 @default.
• W1615702087 cites W2045480275 @default.
• W1615702087 cites W2046118963 @default.
• W1615702087 cites W2048655673 @default.
• W1615702087 cites W2050367310 @default.
• W1615702087 cites W2055038764 @default.
• W1615702087 cites W2082879536 @default.
• W1615702087 cites W2088929386 @default.
• W1615702087 cites W2102210313 @default.
• W1615702087 cites W2112317454 @default.
• W1615702087 cites W2118926394 @default.
• W1615702087 cites W2119390770 @default.
• W1615702087 cites W2121649071 @default.
• W1615702087 cites W2124070987 @default.
• W1615702087 cites W2127030655 @default.
• W1615702087 cites W2128900719 @default.
• W1615702087 cites W2141823673 @default.
• W1615702087 cites W2161053030 @default.
• W1615702087 cites W2171987230 @default.
• W1615702087 cites W2601704071 @default.
• W1615702087 cites W4252021281 @default.
• W1615702087 doi "https://doi.org/10.1111/j.1365-2362.2012.02706.x" @default.
• W1615702087 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22958216" @default.
• W1615702087 hasPublicationYear "2012" @default.
• W1615702087 type Work @default.
• W1615702087 sameAs 1615702087 @default.
• W1615702087 citedByCount "87" @default.
• W1615702087 countsByYear W16157020872013 @default.
• W1615702087 countsByYear W16157020872014 @default.
• W1615702087 countsByYear W16157020872015 @default.
• W1615702087 countsByYear W16157020872016 @default.
• W1615702087 countsByYear W16157020872017 @default.
• W1615702087 countsByYear W16157020872018 @default.
• W1615702087 countsByYear W16157020872019 @default.
• W1615702087 countsByYear W16157020872020 @default.
• W1615702087 countsByYear W16157020872021 @default.
• W1615702087 countsByYear W16157020872022 @default.
• W1615702087 countsByYear W16157020872023 @default.
• W1615702087 crossrefType "journal-article" @default.
• W1615702087 hasAuthorship W1615702087A5021719486 @default.
• W1615702087 hasAuthorship W1615702087A5026866614 @default.
• W1615702087 hasAuthorship W1615702087A5029876130 @default.
• W1615702087 hasAuthorship W1615702087A5032016800 @default.
• W1615702087 hasAuthorship W1615702087A5076852689 @default.
• W1615702087 hasAuthorship W1615702087A5084685500 @default.
• W1615702087 hasConcept C126322002 @default.
• W1615702087 hasConcept C134018914 @default.
• W1615702087 hasConcept C140137476 @default.
• W1615702087 hasConcept C141359234 @default.
• W1615702087 hasConcept C181199279 @default.
• W1615702087 hasConcept C185592680 @default.
• W1615702087 hasConcept C2776175330 @default.
• W1615702087 hasConcept C2778163477 @default.
• W1615702087 hasConcept C2778435403 @default.
• W1615702087 hasConcept C2778772119 @default.
• W1615702087 hasConcept C2778913445 @default.
• W1615702087 hasConcept C2779134260 @default.
• W1615702087 hasConcept C2779318131 @default.
• W1615702087 hasConcept C4733338 @default.
• W1615702087 hasConcept C48289651 @default.
• W1615702087 hasConcept C55493867 @default.
• W1615702087 hasConcept C62231903 @default.
• W1615702087 hasConcept C71924100 @default.
• W1615702087 hasConcept C82714985 @default.
• W1615702087 hasConcept C86803240 @default.
• W1615702087 hasConceptScore W1615702087C126322002 @default.
• W1615702087 hasConceptScore W1615702087C134018914 @default.
• W1615702087 hasConceptScore W1615702087C140137476 @default.
• W1615702087 hasConceptScore W1615702087C141359234 @default.
• W1615702087 hasConceptScore W1615702087C181199279 @default.
• W1615702087 hasConceptScore W1615702087C185592680 @default.
• W1615702087 hasConceptScore W1615702087C2776175330 @default.

• next