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• W1615967354 abstract "Tumor growth and metastasis are angiogenesis-dependent processes initiated and regulated by a number of cytokines. Vascular endothelial growth factor (VEGF) is a potent angiogenic protein with a selective mitogenic effect on vascular endothelial cells. Osteopontin (OPN) induces endothelial cell migration and upregulates endothelial cell migration induced by VEGF. To clarify the cooperative role of VEGF and OPN in tumor angiogenesis, we stained VEGF, OPN, and CD34 immunohistochemically in 87 cases of stage I non-small cell lung cancer (adenocarcinoma, 55, and squamous cell carcinoma, 32). Of the 87 patients studied, 27 patients had postoperative relapse and 60 patients did not. VEGF was found in 34 of 55 cases of adenocarcinomas and 14 of 32 squamous cell carcinomas, and OPN was found in 30 of 55 adenocarcinomas and 10 of 32 squamous cell carcinomas. In adenocarcinoma, microvessel counts of VEGF-positive and OPN-positive tumors were significantly higher than VEGF-negative and OPN-negative tumors, respectively, whereas in squamous cell carcinoma they were not. More importantly, patients with VEGF- and OPN-positive stage I lung adenocarcinoma had significantly worse prognosis as compared with other groups. Cooperation of OPN is important in VEGF-mediated tumor angiogenesis in stage I lung adenocarcinoma. Shijubo N, Uede T, Kon S, Maeda M, Segawa T, Imada A, Hirasawa M, Abe S. Vascular endothelial growth factor and osteopontin in stage I lung adenocarcinoma. AM J RESPIR CRIT CARE MED 1999;160:1269‐1273. Tumor angiogenesis is certainly one of the most important factors involved in the development and progression of some solid human tumors (1, 2). Recent studies (3‐10) have demonstrated that angiogenesis assessed by microvessel counts (MVCs) is closely related to postoperative relapse, especially distant metastasis, indicating that MVC within tumors is a prognostic factor in non‐small cell lung carcinoma (NSCLC), especially stage I NSCLC. Vascular endothelial growth factor (VEGF) is a potent angiogenic protein with a selective mitogenic effect on vascular endothelial cells, known to be involved in physiologic (embryogenesis) and pathophysiologic (rheumatoid arthritis, tumor) angiogenesis (11‐13). Recent investigations (10, 14‐17) have demonstrated that VEGF is a significant cytokine in angiogenesis of lung cancer, and its expression correlates with clinical outcome. Our recent study (10) has documented a wide distribution of MVCs in VEGF-positive stage I lung adenocarcinoma. VEGF is shown to stimulate endothelial cell migration through cooperative mechanisms involving interaction of integrin a v b 3 and osteopontin (OPN) (18). OPN expression is observed in human cancers (19‐22), and OPN expression has been reported to be associated with tumor progression and metastasis in breast cancer (22) and gastric cancer (23). We hypothesized that VEGF-mediated tumor angiogenesis is upregulated in the presence of OPN in lung cancer. The present study was designed to investigate immunohistochemistry of VEGF, OPN, and CD34 in 87 cases of stage I NSCLC and analyze the clinical outcome in patients with stage I NSCLC." @default.
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• W1615967354 date "1999-01-01" @default.
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• W1615967354 title "Vascular endothelial growth factor and osteopontin in stage I′ lung adenocarcinoma." @default.
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