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• W1616028725 abstract "Research Article1 September 1989free access Alternating purine-pyrimidine tracts may promote chromosomal translocations seen in a variety of human lymphoid tumours. T. Boehm T. Boehm Laboratory of Molecular Biology, Cambridge, UK. Search for more papers by this author L. Mengle-Gaw L. Mengle-Gaw Laboratory of Molecular Biology, Cambridge, UK. Search for more papers by this author U.R. Kees U.R. Kees Laboratory of Molecular Biology, Cambridge, UK. Search for more papers by this author N. Spurr N. Spurr Laboratory of Molecular Biology, Cambridge, UK. Search for more papers by this author I. Lavenir I. Lavenir Laboratory of Molecular Biology, Cambridge, UK. Search for more papers by this author A. Forster A. Forster Laboratory of Molecular Biology, Cambridge, UK. Search for more papers by this author T.H. Rabbitts T.H. Rabbitts Laboratory of Molecular Biology, Cambridge, UK. Search for more papers by this author T. Boehm T. Boehm Laboratory of Molecular Biology, Cambridge, UK. Search for more papers by this author L. Mengle-Gaw L. Mengle-Gaw Laboratory of Molecular Biology, Cambridge, UK. Search for more papers by this author U.R. Kees U.R. Kees Laboratory of Molecular Biology, Cambridge, UK. Search for more papers by this author N. Spurr N. Spurr Laboratory of Molecular Biology, Cambridge, UK. Search for more papers by this author I. Lavenir I. Lavenir Laboratory of Molecular Biology, Cambridge, UK. Search for more papers by this author A. Forster A. Forster Laboratory of Molecular Biology, Cambridge, UK. Search for more papers by this author T.H. Rabbitts T.H. Rabbitts Laboratory of Molecular Biology, Cambridge, UK. Search for more papers by this author Author Information T. Boehm1, L. Mengle-Gaw1, U.R. Kees1, N. Spurr1, I. Lavenir1, A. Forster1 and T.H. Rabbitts1 1Laboratory of Molecular Biology, Cambridge, UK. The EMBO Journal (1989)8:2621-2631https://doi.org/10.1002/j.1460-2075.1989.tb08402.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info Chromosomal abnormalities which are prevalent in human lymphoid tumours are believed to be involved in tumour pathogenesis and their formation may be the result of erroneous activity by the V-D-J recombinase. Frequently, recombinase accessibility is provided by prior transcription of the chromosomal regions involved. However, this may not always be so and in those cases DNA structural features must be involved. Here we examine the breakpoints of three different tumour-specific translocations in the proximity of which we can detect no transcription; two of the translocations involve regions of chromosome 11, (t[11;14] [p13;q11] and t[11;14] [q13;q32]), and the third is a newly described translocation, t[7;10] [q35;q24], involving the T cell receptor beta-gene on chromosome 7. In each case, a purine--pyrimidine tract (potential Z-DNA) occurs near the translocation breakpoints. Four independent tumours with translocation t[11;14] [p13;q11] reveal a 2 kb breakpoint cluster region at 11p13 with an adjacent potential Z-DNA region of 62 bp in length; the analogous purine--pyrimidine tract at 10q24 is 32 bp long. The purine--pyrimidine tract at the 11q13 chromosome breakpoint, however, is very large as it covers approximately 800 bp. The position, surrounding sequence and potential Z-DNA tract of the human 11p13 TALLber is conserved in rodents. These results suggest that the purine--pyrimidine tracts, presumably in the Z-DNA form, can influence chromatin structure giving access for recombinase-mediated translocations. Such putative alterations of chromatin organization are supported by the observation of DNase I hypersensitive sites near to translocation breakpoints on 10q24 and 11p13. Previous ArticleNext Article Volume 8Issue 91 September 1989In this issue RelatedDetailsLoading ..." @default.
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• W1616028725 title "Alternating purine-pyrimidine tracts may promote chromosomal translocations seen in a variety of human lymphoid tumours." @default.
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• W1616028725 doi "https://doi.org/10.1002/j.1460-2075.1989.tb08402.x" @default.
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