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• W161603189 endingPage "887" @default.
• W161603189 startingPage "882" @default.
• W161603189 abstract "The role of homocysteine as a risk factor for cardiovascular disease remains controversial because positive reports from case–control studies may be the consequence of reverse causality bias, and positive and negative results have been reported in cohort studies. This is a meta-analysis of published cohort studies. An average relative risk (ARR) was calculated using fixed and random effect models. The likelihood of publication and selection bias, and the impact of each study on the ARR were also evaluated. Fourteen eligible studies were retrieved. We found no evidence of publication bias (P = .62) nor heterogeneity (P = .56). The ARRs from a fixed effect model were 1.49 (95% CI: 1.31–1.70) for cardiac events, and 1.37 (95% CI: 0.99– 1.99) for ischemic stroke. Duration of follow up and age did not significantly change the ARRs. Hyperhomocysteinemia moderately increases the risk of a first cardiovascular event, regardless of age and follow-up duration." @default.
• W161603189 created "2016-06-24" @default.
• W161603189 creator A5016134507 @default.
• W161603189 creator A5031757398 @default.
• W161603189 creator A5043708625 @default.
• W161603189 creator A5075988051 @default.
• W161603189 date "2002-09-01" @default.
• W161603189 modified "2023-10-16" @default.
• W161603189 title "Total plasma homocysteine level and risk of cardiovascular disease" @default.
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• W161603189 doi "https://doi.org/10.1016/s0895-4356(02)00434-1" @default.
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