Matches in SemOpenAlex for { <https://semopenalex.org/work/W16165004> ?p ?o ?g. }
- W16165004 endingPage "9" @default.
- W16165004 startingPage "365" @default.
- W16165004 abstract "Autoimmune prostatitis developed spontaneously in (C57BL/6N x A/J)F1 (B6A) mice, when thymectomy (Tx) was conducted on day 3 after birth (Tx-3). The lesion could be prevented by a single injection of CD4+ spleen cells (4 x 10(6)) from normal males, but not from normal females or newborn orchidectomized (Orx-0) mice. However, when spleen cells were obtained from Orx-0 mice that had received a dihydrotestosterone (DHT) pellet when adult to develop a mature prostate, prostatitis could be prevented, suggesting that immune tolerance to prostate antigen(s) is maintained by a CD4+ tissue-specific suppressor T cell (Ts) population(s), which is activated by a specific autoantigen(s) in the mature prostate. The result that even CD4+ cells from Orx-0 mice that were thymectomized as adults and treated thereafter with DHT were effective for prevention of prostatitis suggests that activation of this Ts population takes place in the peripheral lymphoid organs, and that it maintains peripheral tolerance to autoantigen in the prostate of these mice and probably also in normal mice." @default.
- W16165004 created "2016-06-24" @default.
- W16165004 creator A5023903693 @default.
- W16165004 creator A5024752284 @default.
- W16165004 creator A5028451977 @default.
- W16165004 creator A5039133602 @default.
- W16165004 creator A5057460944 @default.
- W16165004 creator A5060560135 @default.
- W16165004 date "1994-07-01" @default.
- W16165004 modified "2023-09-25" @default.
- W16165004 title "Tissue-specific suppressor T cells involved in self-tolerance are activated extrathymically by self-antigens." @default.
- W16165004 cites W1495115646 @default.
- W16165004 cites W1536609760 @default.
- W16165004 cites W1556016908 @default.
- W16165004 cites W1975216258 @default.
- W16165004 cites W1982081931 @default.
- W16165004 cites W1992897374 @default.
- W16165004 cites W1995313125 @default.
- W16165004 cites W2007362831 @default.
- W16165004 cites W2018869556 @default.
- W16165004 cites W2019522474 @default.
- W16165004 cites W2053670375 @default.
- W16165004 cites W2057846726 @default.
- W16165004 cites W2077117628 @default.
- W16165004 cites W2081475421 @default.
- W16165004 cites W2085262371 @default.
- W16165004 cites W2122756886 @default.
- W16165004 cites W2144557961 @default.
- W16165004 cites W2152088959 @default.
- W16165004 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1414875" @default.
- W16165004 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7959869" @default.
- W16165004 hasPublicationYear "1994" @default.
- W16165004 type Work @default.
- W16165004 sameAs 16165004 @default.
- W16165004 citedByCount "21" @default.
- W16165004 countsByYear W161650042012 @default.
- W16165004 countsByYear W161650042014 @default.
- W16165004 countsByYear W161650042015 @default.
- W16165004 countsByYear W161650042018 @default.
- W16165004 countsByYear W161650042022 @default.
- W16165004 countsByYear W161650042023 @default.
- W16165004 crossrefType "journal-article" @default.
- W16165004 hasAuthorship W16165004A5023903693 @default.
- W16165004 hasAuthorship W16165004A5024752284 @default.
- W16165004 hasAuthorship W16165004A5028451977 @default.
- W16165004 hasAuthorship W16165004A5039133602 @default.
- W16165004 hasAuthorship W16165004A5057460944 @default.
- W16165004 hasAuthorship W16165004A5060560135 @default.
- W16165004 hasConcept C121608353 @default.
- W16165004 hasConcept C126322002 @default.
- W16165004 hasConcept C134018914 @default.
- W16165004 hasConcept C147483822 @default.
- W16165004 hasConcept C203014093 @default.
- W16165004 hasConcept C2776235491 @default.
- W16165004 hasConcept C2777702733 @default.
- W16165004 hasConcept C2777911890 @default.
- W16165004 hasConcept C2778105408 @default.
- W16165004 hasConcept C2779615886 @default.
- W16165004 hasConcept C2779881493 @default.
- W16165004 hasConcept C2780524745 @default.
- W16165004 hasConcept C2780931953 @default.
- W16165004 hasConcept C2908647359 @default.
- W16165004 hasConcept C71315377 @default.
- W16165004 hasConcept C71924100 @default.
- W16165004 hasConcept C86803240 @default.
- W16165004 hasConcept C8891405 @default.
- W16165004 hasConcept C99454951 @default.
- W16165004 hasConceptScore W16165004C121608353 @default.
- W16165004 hasConceptScore W16165004C126322002 @default.
- W16165004 hasConceptScore W16165004C134018914 @default.
- W16165004 hasConceptScore W16165004C147483822 @default.
- W16165004 hasConceptScore W16165004C203014093 @default.
- W16165004 hasConceptScore W16165004C2776235491 @default.
- W16165004 hasConceptScore W16165004C2777702733 @default.
- W16165004 hasConceptScore W16165004C2777911890 @default.
- W16165004 hasConceptScore W16165004C2778105408 @default.
- W16165004 hasConceptScore W16165004C2779615886 @default.
- W16165004 hasConceptScore W16165004C2779881493 @default.
- W16165004 hasConceptScore W16165004C2780524745 @default.
- W16165004 hasConceptScore W16165004C2780931953 @default.
- W16165004 hasConceptScore W16165004C2908647359 @default.
- W16165004 hasConceptScore W16165004C71315377 @default.
- W16165004 hasConceptScore W16165004C71924100 @default.
- W16165004 hasConceptScore W16165004C86803240 @default.
- W16165004 hasConceptScore W16165004C8891405 @default.
- W16165004 hasConceptScore W16165004C99454951 @default.
- W16165004 hasIssue "3" @default.
- W16165004 hasLocation W161650041 @default.
- W16165004 hasOpenAccess W16165004 @default.
- W16165004 hasPrimaryLocation W161650041 @default.
- W16165004 hasRelatedWork W1217682272 @default.
- W16165004 hasRelatedWork W16165004 @default.
- W16165004 hasRelatedWork W1979439339 @default.
- W16165004 hasRelatedWork W2011183043 @default.
- W16165004 hasRelatedWork W2035178547 @default.
- W16165004 hasRelatedWork W2048089653 @default.
- W16165004 hasRelatedWork W2069483580 @default.
- W16165004 hasRelatedWork W2204568656 @default.