FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1616609459> ?p ?o ?g. }

• W1616609459 endingPage "2101" @default.
• W1616609459 startingPage "2095" @default.
• W1616609459 abstract "BackgroundA more aggressive posture toward resection of the dilated aorta has been advocated when associated with bicuspid aortic valve (BAV), based on the notion that aortic material properties are weaker in this setting despite scant data to support or refute this position. The hypothesis that histologic abnormality reflects aortic wall strength was tested by comparing aortas from patients with BAV and trileaflet aortic valve.MethodsResected aortas associated with BAV (n = 60) and trileaflet aortic valve (n = 24) were compared with normal diameter aortas from patients undergoing cardiac transplantation (n = 16) by five histologic criteria: elastic fiber loss (graded 0–4), smooth muscle cell loss (graded 0–4), medial proteoglycan accumulation (graded 0–3), medial fibrosis (graded 0–3), and atherosclerosis (graded 0–3). Patients with known connective tissue disorders, systemic inflammatory conditions, dissection, or prior heart surgery were excluded.ResultsPatients with BAV were a decade younger and more often had functional stenosis. The extent of elastic fiber loss, smooth muscle cell loss, medial fibrosis, and atherosclerosis was more severe in trileaflet aortic valve than BAV when considered across all diameters and when stratified to those between 4 and 5 cm.ConclusionsMore severe histologic abnormalities associated with trileaflet aortic valve compared with BAV, especially when stratified by diameter, do not support a more aggressive approach to surgical intervention for dilatation associated with BAV. Indeed, if based on histologic diagnosis alone, our findings are suggestive that the converse might be true. Additionally, the lack of correlation between aortic diameter and histologic abnormality in the setting of BAV highlights the inadequacy of diameter alone as a criterion for aortic resection. A more aggressive posture toward resection of the dilated aorta has been advocated when associated with bicuspid aortic valve (BAV), based on the notion that aortic material properties are weaker in this setting despite scant data to support or refute this position. The hypothesis that histologic abnormality reflects aortic wall strength was tested by comparing aortas from patients with BAV and trileaflet aortic valve. Resected aortas associated with BAV (n = 60) and trileaflet aortic valve (n = 24) were compared with normal diameter aortas from patients undergoing cardiac transplantation (n = 16) by five histologic criteria: elastic fiber loss (graded 0–4), smooth muscle cell loss (graded 0–4), medial proteoglycan accumulation (graded 0–3), medial fibrosis (graded 0–3), and atherosclerosis (graded 0–3). Patients with known connective tissue disorders, systemic inflammatory conditions, dissection, or prior heart surgery were excluded. Patients with BAV were a decade younger and more often had functional stenosis. The extent of elastic fiber loss, smooth muscle cell loss, medial fibrosis, and atherosclerosis was more severe in trileaflet aortic valve than BAV when considered across all diameters and when stratified to those between 4 and 5 cm. More severe histologic abnormalities associated with trileaflet aortic valve compared with BAV, especially when stratified by diameter, do not support a more aggressive approach to surgical intervention for dilatation associated with BAV. Indeed, if based on histologic diagnosis alone, our findings are suggestive that the converse might be true. Additionally, the lack of correlation between aortic diameter and histologic abnormality in the setting of BAV highlights the inadequacy of diameter alone as a criterion for aortic resection." @default.
• W1616609459 created "2016-06-24" @default.
• W1616609459 creator A5013479170 @default.
• W1616609459 creator A5022563058 @default.
• W1616609459 creator A5028473517 @default.
• W1616609459 creator A5041189964 @default.
• W1616609459 creator A5064387909 @default.
• W1616609459 creator A5074596928 @default.
• W1616609459 date "2015-12-01" @default.
• W1616609459 modified "2023-09-29" @default.
• W1616609459 title "Comparative Histology of Aortic Dilatation Associated With Bileaflet Versus Trileaflet Aortic Valves" @default.
• W1616609459 cites W1963977555 @default.
• W1616609459 cites W1971113143 @default.
• W1616609459 cites W1972809008 @default.
• W1616609459 cites W1979150276 @default.
• W1616609459 cites W1992596289 @default.
• W1616609459 cites W1993863403 @default.
• W1616609459 cites W1996224832 @default.
• W1616609459 cites W1996793705 @default.
• W1616609459 cites W1999365984 @default.
• W1616609459 cites W2007003367 @default.
• W1616609459 cites W2021595870 @default.
• W1616609459 cites W2024154181 @default.
• W1616609459 cites W2039537458 @default.
• W1616609459 cites W2063255660 @default.
• W1616609459 cites W2078002376 @default.
• W1616609459 cites W2080589020 @default.
• W1616609459 cites W2081189235 @default.
• W1616609459 cites W2086227660 @default.
• W1616609459 cites W2107730622 @default.
• W1616609459 cites W2127167942 @default.
• W1616609459 cites W2134260441 @default.
• W1616609459 cites W2137277243 @default.
• W1616609459 cites W2140541589 @default.
• W1616609459 cites W2148715658 @default.
• W1616609459 cites W2152535693 @default.
• W1616609459 cites W2161722088 @default.
• W1616609459 cites W2166457346 @default.
• W1616609459 cites W2169260829 @default.
• W1616609459 cites W2466879592 @default.
• W1616609459 doi "https://doi.org/10.1016/j.athoracsur.2015.05.105" @default.
• W1616609459 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26338050" @default.
• W1616609459 hasPublicationYear "2015" @default.
• W1616609459 type Work @default.
• W1616609459 sameAs 1616609459 @default.
• W1616609459 citedByCount "26" @default.
• W1616609459 countsByYear W16166094592016 @default.
• W1616609459 countsByYear W16166094592017 @default.
• W1616609459 countsByYear W16166094592018 @default.
• W1616609459 countsByYear W16166094592019 @default.
• W1616609459 countsByYear W16166094592020 @default.
• W1616609459 countsByYear W16166094592021 @default.
• W1616609459 countsByYear W16166094592022 @default.
• W1616609459 countsByYear W16166094592023 @default.
• W1616609459 crossrefType "journal-article" @default.
• W1616609459 hasAuthorship W1616609459A5013479170 @default.
• W1616609459 hasAuthorship W1616609459A5022563058 @default.
• W1616609459 hasAuthorship W1616609459A5028473517 @default.
• W1616609459 hasAuthorship W1616609459A5041189964 @default.
• W1616609459 hasAuthorship W1616609459A5064387909 @default.
• W1616609459 hasAuthorship W1616609459A5074596928 @default.
• W1616609459 hasBestOaLocation W16166094591 @default.
• W1616609459 hasConcept C126322002 @default.
• W1616609459 hasConcept C141071460 @default.
• W1616609459 hasConcept C164705383 @default.
• W1616609459 hasConcept C2779980429 @default.
• W1616609459 hasConcept C2780007028 @default.
• W1616609459 hasConcept C2780559512 @default.
• W1616609459 hasConcept C2780714102 @default.
• W1616609459 hasConcept C2781355080 @default.
• W1616609459 hasConcept C2781414266 @default.
• W1616609459 hasConcept C2910672364 @default.
• W1616609459 hasConcept C71924100 @default.
• W1616609459 hasConceptScore W1616609459C126322002 @default.
• W1616609459 hasConceptScore W1616609459C141071460 @default.
• W1616609459 hasConceptScore W1616609459C164705383 @default.
• W1616609459 hasConceptScore W1616609459C2779980429 @default.
• W1616609459 hasConceptScore W1616609459C2780007028 @default.
• W1616609459 hasConceptScore W1616609459C2780559512 @default.
• W1616609459 hasConceptScore W1616609459C2780714102 @default.
• W1616609459 hasConceptScore W1616609459C2781355080 @default.
• W1616609459 hasConceptScore W1616609459C2781414266 @default.
• W1616609459 hasConceptScore W1616609459C2910672364 @default.
• W1616609459 hasConceptScore W1616609459C71924100 @default.
• W1616609459 hasIssue "6" @default.
• W1616609459 hasLocation W16166094591 @default.
• W1616609459 hasOpenAccess W1616609459 @default.
• W1616609459 hasPrimaryLocation W16166094591 @default.
• W1616609459 hasRelatedWork W2030142275 @default.
• W1616609459 hasRelatedWork W2081625292 @default.
• W1616609459 hasRelatedWork W2092848625 @default.
• W1616609459 hasRelatedWork W2128213390 @default.
• W1616609459 hasRelatedWork W2134855279 @default.
• W1616609459 hasRelatedWork W2468474977 @default.
• W1616609459 hasRelatedWork W2999943364 @default.
• W1616609459 hasRelatedWork W3097607593 @default.
• W1616609459 hasRelatedWork W4210497008 @default.
• W1616609459 hasRelatedWork W62681953 @default.

• next