Matches in SemOpenAlex for { <https://semopenalex.org/work/W161665780> ?p ?o ?g. }
- W161665780 abstract "Purinergic signaling is a crucial component of disease whose pathophysiological basis is now well established. This review focuses on P2X(7), a unique bifunctional purinoreceptor that either opens a non selective cation channel or forms a large, cytolytic pore depending on agonist application and leading to membrane blebbing and to cell death either by necrosis or apoptosis.Activation of P2X(7) receptor has been shown to stimulate the release of multiple proinflammatory cytokines by activated macrophages, with the IL-1b to be the most extensively studied among them. These findings were verified by the use of knockout P2X(7) ((-/-)) mice.Update information coming from all fields of research implicate this receptor at the very heart of diseases such as rheumatoid arthritis, multiple sclerosis, depression, Alzheimer disease, and to kidney damage, in renal fibrosis and experimental nephritis.Clinical studies are currently underway with the newly developed selective antagonists for P2X(7) receptor, the results of which are eagerly anticipated. These studies together with data from in-vivo experiments with the P2X(7) knockout mice and in-vitro experiments will shed light in this exciting area." @default.
- W161665780 created "2016-06-24" @default.
- W161665780 creator A5003294070 @default.
- W161665780 creator A5055232769 @default.
- W161665780 creator A5057910483 @default.
- W161665780 creator A5059544439 @default.
- W161665780 date "2010-07-01" @default.
- W161665780 modified "2023-09-23" @default.
- W161665780 title "P2X(7) receptor at the heart of disease." @default.
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