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• W161716621 abstract "Jouvet has implicated 5-hydroxytryptamine (5-HT, serotonin) in the regulation of slow-wave sleep (SWS). He and his co-workers showed that subtotal destruction of the raphe nuclei decreased the level of 5-HT in the brain and led to a state of severe insomnia (Jouvet et al., 1966) and that the injection of p-chlorophenylalanine (pCPA), which inhibits 5-HT synthesis, produced similar results (Delorme et al., 1966). This effect was reversed by administration of 5-hydroxytryptophan (5-HTP), a precursor of 5-HT, which restored SWS and paradoxical sleep (PS)." @default.
• W161716621 created "2016-06-24" @default.
• W161716621 creator A5011835654 @default.
• W161716621 date "1974-01-01" @default.
• W161716621 modified "2023-09-23" @default.
• W161716621 title "5-Hydroxyindoleacetic Acid in Cerebrospinal Fluid During Wakefulness, Sleep and After Electrical Stimulation of Specific Brain Structures" @default.
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• W161716621 doi "https://doi.org/10.1007/978-1-4684-3066-0_15" @default.
• W161716621 hasPublicationYear "1974" @default.
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