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- W161718557 abstract "Platelet-activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphoryl-choline) is an alkylether phospholipid that possesses a wide range of biological effects in many physiological and pathological responses such as platelet aggregation, neutrophil chemotaxis, macrophage activation, blood pressure regulation, or smooth muscle contraction (1–7). PAF was also recently shown to be a potentially important signaling molecule in neuronal signal transduction (8–11). While the Ca2+-dependent synthesis and catabolism of PAF still remain to be fully characterized, converging lines of evidence suggested the existence of a specific surface receptor for PAF in diverse systems (5–7). Recent molecular cloning of PAF receptors from various species (12–16) has enabled to obtain further insights in the diverse biological functions and signaling mechanisms mediated through this receptor. In this proceeding, we will focus on the molecular structure of PAF receptor, its gene regulation and its multiple signal transduction pathways." @default.
- W161718557 created "2016-06-24" @default.
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- W161718557 date "1997-01-01" @default.
- W161718557 modified "2023-10-17" @default.
- W161718557 title "Molecular Characterization and Physiological Functions of PAF Receptors" @default.
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- W161718557 doi "https://doi.org/10.1007/978-1-4615-5325-0_31" @default.
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