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• W1617229181 abstract "Background and purpose: Cell‐to‐cell interactions between mast cells and activated T cells are increasingly recognized as a possible mechanism in the aetiology of allergic or non‐allergic inflammatory disorders. To determine the anti‐allergic effect of fisetin, we examined the ability of fisetin to suppress activation of the human mast cell line, HMC‐1, induced by activated Jurkat T cell membranes. Experimental approach: HMC‐1 cells were incubated with or without fisetin for 15 min and then co‐cultured with Jurkat T cell membranes activated by phorbol‐12‐myristate 13‐acetate for 16 h. We determined gene expression in activated HMC‐1 cells by DNA microarray and quantitative reverse transcription (RT)‐PCR analysis. We also examined activation of the transcription factor NF‐κB and MAP kinases (MAPKs) in activated HMC‐1 cells. Key results: Fisetin suppresses cell spreading and gene expression in HMC‐1 cells stimulated by activated T cell membranes. Additionally, we show that these stimulated HMC‐1 cells expressed granzyme B. The stimulatory interaction also induced activation of NF‐κB and MAPKs; these activations were suppressed by fisetin. Fisetin also reduced the amount of cell surface antigen CD40 and intercellular adhesion molecule‐1 (ICAM‐1) on activated HMC‐1 cells. Conclusions and implications: Fisetin suppressed activation of HMC‐1 cells by activated T cell membranes by interfering with cell‐to‐cell interaction and inhibiting the activity of NF‐κB and MAPKs and thereby suppressing gene expression. Fisetin may protect against the progression of inflammatory diseases by limiting interactions between mast cells and activated T cells." @default.
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• W1617229181 date "2009-10-01" @default.
• W1617229181 modified "2023-10-16" @default.
• W1617229181 title "The hydroxyflavone, fisetin, suppresses mast cell activation induced by interaction with activated T cell membranes" @default.
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• W1617229181 doi "https://doi.org/10.1111/j.1476-5381.2009.00365.x" @default.
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