FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1617303364> ?p ?o ?g. }

• W1617303364 endingPage "7712" @default.
• W1617303364 startingPage "7706" @default.
• W1617303364 abstract "Activated mast cells are a major source of the eicosanoids PGD(2) and leukotriene C(4) (LTC(4)), which contribute to allergic responses. These eicosanoids are produced following the ERK1/2-dependent activation of cytosolic phospholipase A(2), thus liberating arachidonic acid, which is subsequently metabolized by the actions of 5-lipoxygenase and cyclooxygenase to form LTC(4) and PGD(2), respectively. These pathways also generate reactive oxygen species (ROS), which have been proposed to contribute to FcepsilonRI-mediated signaling in mast cells. In this study, we demonstrate that, in addition to ERK1/2-dependent pathways, ERK1/2-independent pathways also regulate FcepsilonRI-mediated eicosanoid and ROS production in mast cells. A role for the Tec kinase Btk in the ERK1/2-independent regulatory pathway was revealed by the significantly attenuated FcepsilonRI-dependent PGD(2), LTC(4), and ROS production in bone marrow-derived mast cells of Btk(-/-) mice. The FcepsilonRI-dependent activation of Btk and eicosanoid and ROS generation in bone marrow-derived mast cells and human mast cells were similarly blocked by the PI3K inhibitors, Wortmannin and LY294002, indicating that Btk-regulated eicosanoid and ROS production occurs downstream of PI3K. In contrast to ERK1/2, the PI3K/Btk pathway does not regulate cytosolic phospholipase A(2) phosphorylation but rather appears to regulate the generation of ROS, LTC(4), and PGD(2) by contributing to the necessary Ca(2+) signal for the production of these molecules. These data demonstrate that strategies to decrease mast cell production of ROS and eicosanoids would have to target both ERK1/2- and PI3K/Btk-dependent pathways." @default.
• W1617303364 created "2016-06-24" @default.
• W1617303364 creator A5011039354 @default.
• W1617303364 creator A5014291386 @default.
• W1617303364 creator A5034156385 @default.
• W1617303364 creator A5039320260 @default.
• W1617303364 creator A5059179977 @default.
• W1617303364 creator A5071148405 @default.
• W1617303364 date "2008-12-01" @default.
• W1617303364 modified "2023-10-11" @default.
• W1617303364 title "The Phosphoinositide 3-Kinase-Dependent Activation of Btk Is Required for Optimal Eicosanoid Production and Generation of Reactive Oxygen Species in Antigen-Stimulated Mast Cells" @default.
• W1617303364 cites W1509846900 @default.
• W1617303364 cites W1512231459 @default.
• W1617303364 cites W1567522550 @default.
• W1617303364 cites W1576409357 @default.
• W1617303364 cites W1589012667 @default.
• W1617303364 cites W1773327886 @default.
• W1617303364 cites W1972068952 @default.
• W1617303364 cites W1978243682 @default.
• W1617303364 cites W1991790457 @default.
• W1617303364 cites W2002967758 @default.
• W1617303364 cites W2007187686 @default.
• W1617303364 cites W2009091144 @default.
• W1617303364 cites W2015082452 @default.
• W1617303364 cites W2022188353 @default.
• W1617303364 cites W2025563699 @default.
• W1617303364 cites W2033145757 @default.
• W1617303364 cites W2034203371 @default.
• W1617303364 cites W2038960406 @default.
• W1617303364 cites W2043074579 @default.
• W1617303364 cites W2051958752 @default.
• W1617303364 cites W2056973414 @default.
• W1617303364 cites W2066600235 @default.
• W1617303364 cites W2072696221 @default.
• W1617303364 cites W2074705569 @default.
• W1617303364 cites W2077904086 @default.
• W1617303364 cites W2086923184 @default.
• W1617303364 cites W2143616947 @default.
• W1617303364 cites W2152450698 @default.
• W1617303364 cites W2153539273 @default.
• W1617303364 cites W24802265 @default.
• W1617303364 doi "https://doi.org/10.4049/jimmunol.181.11.7706" @default.
• W1617303364 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2709775" @default.
• W1617303364 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19017959" @default.
• W1617303364 hasPublicationYear "2008" @default.
• W1617303364 type Work @default.
• W1617303364 sameAs 1617303364 @default.
• W1617303364 citedByCount "62" @default.
• W1617303364 countsByYear W16173033642012 @default.
• W1617303364 countsByYear W16173033642013 @default.
• W1617303364 countsByYear W16173033642014 @default.
• W1617303364 countsByYear W16173033642015 @default.
• W1617303364 countsByYear W16173033642016 @default.
• W1617303364 countsByYear W16173033642017 @default.
• W1617303364 countsByYear W16173033642018 @default.
• W1617303364 countsByYear W16173033642019 @default.
• W1617303364 countsByYear W16173033642020 @default.
• W1617303364 countsByYear W16173033642021 @default.
• W1617303364 countsByYear W16173033642022 @default.
• W1617303364 countsByYear W16173033642023 @default.
• W1617303364 crossrefType "journal-article" @default.
• W1617303364 hasAuthorship W1617303364A5011039354 @default.
• W1617303364 hasAuthorship W1617303364A5014291386 @default.
• W1617303364 hasAuthorship W1617303364A5034156385 @default.
• W1617303364 hasAuthorship W1617303364A5039320260 @default.
• W1617303364 hasAuthorship W1617303364A5059179977 @default.
• W1617303364 hasAuthorship W1617303364A5071148405 @default.
• W1617303364 hasBestOaLocation W16173033641 @default.
• W1617303364 hasConcept C170493617 @default.
• W1617303364 hasConcept C180899940 @default.
• W1617303364 hasConcept C181199279 @default.
• W1617303364 hasConcept C185592680 @default.
• W1617303364 hasConcept C203014093 @default.
• W1617303364 hasConcept C2776042228 @default.
• W1617303364 hasConcept C2776352991 @default.
• W1617303364 hasConcept C2776452501 @default.
• W1617303364 hasConcept C2778078955 @default.
• W1617303364 hasConcept C2778308172 @default.
• W1617303364 hasConcept C2779543280 @default.
• W1617303364 hasConcept C2780610907 @default.
• W1617303364 hasConcept C42362537 @default.
• W1617303364 hasConcept C48349386 @default.
• W1617303364 hasConcept C55493867 @default.
• W1617303364 hasConcept C62478195 @default.
• W1617303364 hasConcept C86803240 @default.
• W1617303364 hasConcept C90059517 @default.
• W1617303364 hasConcept C90342290 @default.
• W1617303364 hasConcept C95444343 @default.
• W1617303364 hasConceptScore W1617303364C170493617 @default.
• W1617303364 hasConceptScore W1617303364C180899940 @default.
• W1617303364 hasConceptScore W1617303364C181199279 @default.
• W1617303364 hasConceptScore W1617303364C185592680 @default.
• W1617303364 hasConceptScore W1617303364C203014093 @default.
• W1617303364 hasConceptScore W1617303364C2776042228 @default.
• W1617303364 hasConceptScore W1617303364C2776352991 @default.
• W1617303364 hasConceptScore W1617303364C2776452501 @default.
• W1617303364 hasConceptScore W1617303364C2778078955 @default.
• W1617303364 hasConceptScore W1617303364C2778308172 @default.

• next