Matches in SemOpenAlex for { <https://semopenalex.org/work/W1617307609> ?p ?o ?g. }
- W1617307609 endingPage "445" @default.
- W1617307609 startingPage "437" @default.
- W1617307609 abstract "Microcins B17 and C7 are plasmid-determined, peptide antibiotics produced by Escherichia coli when cells enter the stationary phase of growth. Microcinogenic strains are immune to the action of the microcin they synthesize. A well-characterized deficient-immunity phenotype is exhibited by microcin B17-producing cells in the absence of the immunity gene mcbG (M.C. Garrido, M. Herrero, R. Kolter, and F. Moreno, EMBO J. 7:1853-1862, 1988). A 14.6-kilobase-pair EcoRI chromosomal fragment was isolated by its ability to suppress this phenotype when cloned into a multicopy vector. This fragment was mapped to 57.5 min on the E. coli genetic map. The position of the gene responsible for suppression, designated mprA, was determined by insertional mutagenesis and deletion analysis. mprA was shown to be transcribed clockwise on the E. coli chromosome, and its product was identified as a 19-kilodalton polypeptide. Suppression was shown to be achieved by decreasing microcin B17 production. Increased mprA gene dosage also caused a decrease in microcin C7 production and blocked the osmoinduction of the proU locus in high-osmolarity media. Our results suggest that the mprA gene product could play a regulatory role on expression of several E. coli genes, this control being exerted at the transcriptional level." @default.
- W1617307609 created "2016-06-24" @default.
- W1617307609 creator A5016979897 @default.
- W1617307609 creator A5062929969 @default.
- W1617307609 creator A5067573711 @default.
- W1617307609 date "1990-01-01" @default.
- W1617307609 modified "2023-09-30" @default.
- W1617307609 title "mprA, an Escherichia coli gene that reduces growth-phase-dependent synthesis of microcins B17 and C7 and blocks osmoinduction of proU when cloned on a high-copy-number plasmid" @default.
- W1617307609 cites W1492813001 @default.
- W1617307609 cites W1510689423 @default.
- W1617307609 cites W1552484306 @default.
- W1617307609 cites W1558547246 @default.
- W1617307609 cites W1564031035 @default.
- W1617307609 cites W1572083995 @default.
- W1617307609 cites W1719124555 @default.
- W1617307609 cites W1775650731 @default.
- W1617307609 cites W1836514020 @default.
- W1617307609 cites W1851826491 @default.
- W1617307609 cites W1868954945 @default.
- W1617307609 cites W1881270903 @default.
- W1617307609 cites W1910394702 @default.
- W1617307609 cites W1944875566 @default.
- W1617307609 cites W1948880364 @default.
- W1617307609 cites W1994921867 @default.
- W1617307609 cites W1996066959 @default.
- W1617307609 cites W2017600384 @default.
- W1617307609 cites W2018289835 @default.
- W1617307609 cites W2023364466 @default.
- W1617307609 cites W2026145965 @default.
- W1617307609 cites W2028780813 @default.
- W1617307609 cites W2042814467 @default.
- W1617307609 cites W2043268620 @default.
- W1617307609 cites W2049152293 @default.
- W1617307609 cites W2057481976 @default.
- W1617307609 cites W2063108688 @default.
- W1617307609 cites W2072552035 @default.
- W1617307609 cites W2077036737 @default.
- W1617307609 cites W2091015514 @default.
- W1617307609 cites W2100837269 @default.
- W1617307609 cites W2104502549 @default.
- W1617307609 cites W2114788678 @default.
- W1617307609 cites W2116944773 @default.
- W1617307609 cites W2135786672 @default.
- W1617307609 cites W2137180677 @default.
- W1617307609 cites W2139261128 @default.
- W1617307609 cites W2141653906 @default.
- W1617307609 cites W2143207948 @default.
- W1617307609 cites W2151533084 @default.
- W1617307609 cites W2463267938 @default.
- W1617307609 cites W2916217134 @default.
- W1617307609 cites W4240149779 @default.
- W1617307609 cites W4247438397 @default.
- W1617307609 cites W4296765338 @default.
- W1617307609 doi "https://doi.org/10.1128/jb.172.1.437-445.1990" @default.
- W1617307609 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/208450" @default.
- W1617307609 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2152912" @default.
- W1617307609 hasPublicationYear "1990" @default.
- W1617307609 type Work @default.
- W1617307609 sameAs 1617307609 @default.
- W1617307609 citedByCount "44" @default.
- W1617307609 countsByYear W16173076092014 @default.
- W1617307609 countsByYear W16173076092016 @default.
- W1617307609 countsByYear W16173076092017 @default.
- W1617307609 crossrefType "journal-article" @default.
- W1617307609 hasAuthorship W1617307609A5016979897 @default.
- W1617307609 hasAuthorship W1617307609A5062929969 @default.
- W1617307609 hasAuthorship W1617307609A5067573711 @default.
- W1617307609 hasBestOaLocation W16173076091 @default.
- W1617307609 hasConcept C104317684 @default.
- W1617307609 hasConcept C107635520 @default.
- W1617307609 hasConcept C143065580 @default.
- W1617307609 hasConcept C150194340 @default.
- W1617307609 hasConcept C153911025 @default.
- W1617307609 hasConcept C195286587 @default.
- W1617307609 hasConcept C22744801 @default.
- W1617307609 hasConcept C54355233 @default.
- W1617307609 hasConcept C547475151 @default.
- W1617307609 hasConcept C55548728 @default.
- W1617307609 hasConcept C86803240 @default.
- W1617307609 hasConceptScore W1617307609C104317684 @default.
- W1617307609 hasConceptScore W1617307609C107635520 @default.
- W1617307609 hasConceptScore W1617307609C143065580 @default.
- W1617307609 hasConceptScore W1617307609C150194340 @default.
- W1617307609 hasConceptScore W1617307609C153911025 @default.
- W1617307609 hasConceptScore W1617307609C195286587 @default.
- W1617307609 hasConceptScore W1617307609C22744801 @default.
- W1617307609 hasConceptScore W1617307609C54355233 @default.
- W1617307609 hasConceptScore W1617307609C547475151 @default.
- W1617307609 hasConceptScore W1617307609C55548728 @default.
- W1617307609 hasConceptScore W1617307609C86803240 @default.
- W1617307609 hasIssue "1" @default.
- W1617307609 hasLocation W16173076091 @default.
- W1617307609 hasLocation W16173076092 @default.
- W1617307609 hasLocation W16173076093 @default.
- W1617307609 hasLocation W16173076094 @default.
- W1617307609 hasOpenAccess W1617307609 @default.
- W1617307609 hasPrimaryLocation W16173076091 @default.
- W1617307609 hasRelatedWork W1560279942 @default.