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• W161738281 abstract "The purpose of this study was to establish whether material properties of elastin co-electrospun with polydioxanone (PDO) would change over time in both the uncross-linked state and the cross-linked state. First, uncross-linked scaffolds were placed in phosphate buffered saline (PBS) for three separate time periods: 15 minutes, 1 hour, and 24 hours, and subsequently tested using uniaxial materials testing. Several cross-linking reagents were then investigated to verify their ability to crosslink elastin: 1–ethyl-3–(dimethylaminopropyl)-carbodiimide (EDC), ethylene glycol diglycidyl ether (EGDE), and genipin. Uniaxial tensile testing was performed on scaffolds cross-linked with EDC and genipin, yielding results that warranted further investigation for PDO-elastin blends. Material properties of the cross-linked scaffolds were then found within range of both pig femoral artery and human femoral artery. These results demonstrate PDO-elastin blends could potentially be favorable as vascular grafts, thus warranting future in vitro and in vivo studies." @default.
• W161738281 created "2016-06-24" @default.
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• W161738281 date "2008-03-01" @default.
• W161738281 modified "2023-09-27" @default.
• W161738281 title "Cross-linking Electrospun Polydioxanone-Soluble Elastin Blends: Material Characterization" @default.
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• W161738281 doi "https://doi.org/10.1177/155892500800300101" @default.
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