Matches in SemOpenAlex for { <https://semopenalex.org/work/W161796404> ?p ?o ?g. }
- W161796404 endingPage "398" @default.
- W161796404 startingPage "375" @default.
- W161796404 abstract "Peptide–protein interactions are prevalent in the living cell and form a key component of the overall protein–protein interaction network. These interactions are drawing increasing interest due to their part in signaling and regulation, and are thus attractive targets for computational structural modeling. Here we report an overview of current techniques for the high resolution modeling of peptide–protein complexes. We dissect this complicated challenge into several smaller subproblems, namely: modeling the receptor protein, predicting the peptide binding site, sampling an initial peptide backbone conformation and the final refinement of the peptide within the receptor binding site. For each of these conceptual stages, we present available tools, approaches, and their reported performance. We summarize with an illustrative example of this process, highlighting the success and current challenges still facing the automated blind modeling of peptide–protein interactions. We believe that the upcoming years will see considerable progress in our ability to create accurate models of peptide–protein interactions, with applications in binding-specificity prediction, rational design of peptide-mediated interactions and the usage of peptides as therapeutic agents." @default.
- W161796404 created "2016-06-24" @default.
- W161796404 creator A5007097283 @default.
- W161796404 creator A5034150494 @default.
- W161796404 creator A5044428734 @default.
- W161796404 date "2011-01-01" @default.
- W161796404 modified "2023-09-27" @default.
- W161796404 title "Modeling Peptide–Protein Interactions" @default.
- W161796404 cites W1571577887 @default.
- W161796404 cites W1963695198 @default.
- W161796404 cites W1964958542 @default.
- W161796404 cites W1966603445 @default.
- W161796404 cites W1970294718 @default.
- W161796404 cites W1971855004 @default.
- W161796404 cites W1983142511 @default.
- W161796404 cites W1987200512 @default.
- W161796404 cites W1989415425 @default.
- W161796404 cites W1991263759 @default.
- W161796404 cites W1995749884 @default.
- W161796404 cites W1996681913 @default.
- W161796404 cites W2000383223 @default.
- W161796404 cites W2000443388 @default.
- W161796404 cites W2003064029 @default.
- W161796404 cites W2003819264 @default.
- W161796404 cites W2004592603 @default.
- W161796404 cites W2004979216 @default.
- W161796404 cites W2005747738 @default.
- W161796404 cites W2008972431 @default.
- W161796404 cites W2013593586 @default.
- W161796404 cites W2013829952 @default.
- W161796404 cites W2014550271 @default.
- W161796404 cites W2016796493 @default.
- W161796404 cites W2020327873 @default.
- W161796404 cites W2023272942 @default.
- W161796404 cites W2027267610 @default.
- W161796404 cites W2027638447 @default.
- W161796404 cites W2030204844 @default.
- W161796404 cites W2030545797 @default.
- W161796404 cites W2036472425 @default.
- W161796404 cites W2039201738 @default.
- W161796404 cites W2043699100 @default.
- W161796404 cites W2043750862 @default.
- W161796404 cites W2044730187 @default.
- W161796404 cites W2044901882 @default.
- W161796404 cites W2047468595 @default.
- W161796404 cites W2050000500 @default.
- W161796404 cites W2050433784 @default.
- W161796404 cites W2051657109 @default.
- W161796404 cites W2052033556 @default.
- W161796404 cites W2053939374 @default.
- W161796404 cites W2054711926 @default.
- W161796404 cites W2054954101 @default.
- W161796404 cites W2056219928 @default.
- W161796404 cites W2057482592 @default.
- W161796404 cites W2057819166 @default.
- W161796404 cites W2059942519 @default.
- W161796404 cites W2062217029 @default.
- W161796404 cites W2065958975 @default.
- W161796404 cites W2067763399 @default.
- W161796404 cites W2074105113 @default.
- W161796404 cites W2077116876 @default.
- W161796404 cites W2077776336 @default.
- W161796404 cites W2083747978 @default.
- W161796404 cites W2085855259 @default.
- W161796404 cites W2090078310 @default.
- W161796404 cites W2093629170 @default.
- W161796404 cites W2094011899 @default.
- W161796404 cites W2094842122 @default.
- W161796404 cites W2096994057 @default.
- W161796404 cites W2097029677 @default.
- W161796404 cites W2101386484 @default.
- W161796404 cites W2103994532 @default.
- W161796404 cites W2105119251 @default.
- W161796404 cites W2109604654 @default.
- W161796404 cites W2110128290 @default.
- W161796404 cites W2114512254 @default.
- W161796404 cites W2115133023 @default.
- W161796404 cites W2116211618 @default.
- W161796404 cites W2116890528 @default.
- W161796404 cites W2120580958 @default.
- W161796404 cites W2121753315 @default.
- W161796404 cites W2122664553 @default.
- W161796404 cites W2123334353 @default.
- W161796404 cites W2128392882 @default.
- W161796404 cites W2130479394 @default.
- W161796404 cites W2132395520 @default.
- W161796404 cites W2133029485 @default.
- W161796404 cites W2136513242 @default.
- W161796404 cites W2139942857 @default.
- W161796404 cites W2140564438 @default.
- W161796404 cites W2141550775 @default.
- W161796404 cites W2142781521 @default.
- W161796404 cites W2143094533 @default.
- W161796404 cites W2143881057 @default.
- W161796404 cites W2145080853 @default.
- W161796404 cites W2145600320 @default.
- W161796404 cites W2147610376 @default.
- W161796404 cites W2148219066 @default.