Matches in SemOpenAlex for { <https://semopenalex.org/work/W1618241955> ?p ?o ?g. }
- W1618241955 endingPage "2934" @default.
- W1618241955 startingPage "2925" @default.
- W1618241955 abstract "Mature, naive B cells coexpress IgD and IgM with identical binding sites. In this study, the binding properties of such IgM and IgD are compared to determine how size and shape may influence their ability to bind Ag and thus function as receptors. To dissect their intrinsic binding properties, recombinant IgM and IgD were produced in soluble form as monomers of the basic H(2)L(2) Ab architecture, each with two Ag binding sites. Since these sites are connected with a hinge region in IgD and structural Ig domains in IgM, the two molecules differ significantly in this region. The results show that IgD exhibited the larger angle and longer distance between its binding sites, as well as having the greater flexibility. Relative functional affinity was assessed on two antigenic surfaces with high or low epitope density, respectively. At high epitope density, IgM had a higher functional affinity for the Ag compared with IgD. The order was reversed at low epitope density due to a decrease in the functional affinity of IgM. Studies of binding kinetics showed similar association rates for both molecules. The dissociation rate, however, was slower for IgM at high epitope density and for IgD at low epitope density. Taken together, the results show that IgM and IgD with identical Ag binding regions have different Ag binding properties." @default.
- W1618241955 created "2016-06-24" @default.
- W1618241955 creator A5021171035 @default.
- W1618241955 creator A5028008104 @default.
- W1618241955 creator A5038445673 @default.
- W1618241955 creator A5045878198 @default.
- W1618241955 creator A5076160693 @default.
- W1618241955 date "2004-03-01" @default.
- W1618241955 modified "2023-10-18" @default.
- W1618241955 title "Differential Segmental Flexibility and Reach Dictate the Antigen Binding Mode of Chimeric IgD and IgM: Implications for the Function of the B Cell Receptor" @default.
- W1618241955 cites W1244099196 @default.
- W1618241955 cites W129808178 @default.
- W1618241955 cites W1479786190 @default.
- W1618241955 cites W1532365878 @default.
- W1618241955 cites W1560347431 @default.
- W1618241955 cites W1570387503 @default.
- W1618241955 cites W1579796122 @default.
- W1618241955 cites W1591808469 @default.
- W1618241955 cites W1598550305 @default.
- W1618241955 cites W1665022174 @default.
- W1618241955 cites W1666706706 @default.
- W1618241955 cites W1812425905 @default.
- W1618241955 cites W1911278511 @default.
- W1618241955 cites W1959801065 @default.
- W1618241955 cites W1962951638 @default.
- W1618241955 cites W1964220425 @default.
- W1618241955 cites W1966756198 @default.
- W1618241955 cites W1970543296 @default.
- W1618241955 cites W1971178765 @default.
- W1618241955 cites W1975833078 @default.
- W1618241955 cites W1977162206 @default.
- W1618241955 cites W1978401026 @default.
- W1618241955 cites W1979715545 @default.
- W1618241955 cites W1981783209 @default.
- W1618241955 cites W1982597972 @default.
- W1618241955 cites W1983734779 @default.
- W1618241955 cites W1987229882 @default.
- W1618241955 cites W1988376910 @default.
- W1618241955 cites W1995140475 @default.
- W1618241955 cites W1996033648 @default.
- W1618241955 cites W1998771901 @default.
- W1618241955 cites W2005869248 @default.
- W1618241955 cites W2007511503 @default.
- W1618241955 cites W2011500156 @default.
- W1618241955 cites W2012219819 @default.
- W1618241955 cites W2019283439 @default.
- W1618241955 cites W2034847661 @default.
- W1618241955 cites W2039381999 @default.
- W1618241955 cites W2042079029 @default.
- W1618241955 cites W2042936971 @default.
- W1618241955 cites W2046621957 @default.
- W1618241955 cites W2046737111 @default.
- W1618241955 cites W2048362048 @default.
- W1618241955 cites W2050696168 @default.
- W1618241955 cites W2057237815 @default.
- W1618241955 cites W2059320818 @default.
- W1618241955 cites W2063272499 @default.
- W1618241955 cites W2063495909 @default.
- W1618241955 cites W2066144417 @default.
- W1618241955 cites W2070505228 @default.
- W1618241955 cites W2076339600 @default.
- W1618241955 cites W2077201659 @default.
- W1618241955 cites W2078310062 @default.
- W1618241955 cites W2080720215 @default.
- W1618241955 cites W2080740749 @default.
- W1618241955 cites W2081213247 @default.
- W1618241955 cites W2084250362 @default.
- W1618241955 cites W2091174247 @default.
- W1618241955 cites W2092562610 @default.
- W1618241955 cites W2102855728 @default.
- W1618241955 cites W2108791168 @default.
- W1618241955 cites W2117831509 @default.
- W1618241955 cites W2120602481 @default.
- W1618241955 cites W2131074235 @default.
- W1618241955 cites W2153831309 @default.
- W1618241955 cites W2156923776 @default.
- W1618241955 cites W2164633799 @default.
- W1618241955 cites W4321835877 @default.
- W1618241955 cites W72174645 @default.
- W1618241955 doi "https://doi.org/10.4049/jimmunol.172.5.2925" @default.
- W1618241955 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14978095" @default.
- W1618241955 hasPublicationYear "2004" @default.
- W1618241955 type Work @default.
- W1618241955 sameAs 1618241955 @default.
- W1618241955 citedByCount "48" @default.
- W1618241955 countsByYear W16182419552012 @default.
- W1618241955 countsByYear W16182419552013 @default.
- W1618241955 countsByYear W16182419552014 @default.
- W1618241955 countsByYear W16182419552015 @default.
- W1618241955 countsByYear W16182419552016 @default.
- W1618241955 countsByYear W16182419552017 @default.
- W1618241955 countsByYear W16182419552018 @default.
- W1618241955 countsByYear W16182419552019 @default.
- W1618241955 countsByYear W16182419552020 @default.
- W1618241955 countsByYear W16182419552021 @default.
- W1618241955 countsByYear W16182419552022 @default.
- W1618241955 countsByYear W16182419552023 @default.
- W1618241955 crossrefType "journal-article" @default.