Matches in SemOpenAlex for { <https://semopenalex.org/work/W1618474788> ?p ?o ?g. }
- W1618474788 abstract "A large number of new potential chemoprevention agents are available that target molecular abnormalities found in estrogen receptor (ER)-negative and/or ER-positive precancerous breast tissue and have side effect profiles that differ from tamoxifen. Classes of agents currently undergoing evaluation in clinical prevention trials or those for which testing is planned in the near future include new selective ER modulators, aromatase inactivators/inhibitors, gonadotrophin-releasing hormone agonists, monoterpenes, isoflavones, retinoids, rexinoids, vitamin D derivatives, and inhibitors of tyrosine kinase, cyclooxygenase-2, and polyamine synthesis. New clinical testing models will use morphological and molecular biomarkers to select candidates at highest short-term risk, to predict the response to a particular class of agent, and to assess the response in phase II prevention trials. If validated, morphological and molecular markers could eventually replace cancer incidence as an indicator of efficacy in future phase III trials." @default.
- W1618474788 created "2016-06-24" @default.
- W1618474788 creator A5059485304 @default.
- W1618474788 date "2001-04-01" @default.
- W1618474788 modified "2023-10-06" @default.
- W1618474788 title "Breast cancer chemoprevention: beyond tamoxifen" @default.
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- W1618474788 doi "https://doi.org/10.1186/bcr279" @default.
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