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- W16185311 abstract "Selective amino acid restriction inhibits invasion and induces apoptosis of PC3 and DU145 prostate cancer cells. In PC3 cells, Tyr/Phe or Met restriction reduces surface alpha5beta1 integrin expression, and Tyr/Phe or Gln restriction reduces the amount of Ras-GTP. In DU145 cells, Tyr/Phe, Met, or Gln restriction does not affect integrin expression. Tyr/Phe restriction reduces the amount of Rho-GTP and Rac1-GTP. Met deprivation reduces Rho-GTP, and Gln restriction decreases Cdc42-GTP. These effects contribute to decreased invasiveness. Amino acid restriction differentially modulates the Raf and Akt survival pathways to induce apoptosis. In DU145, Tyr/Phe or Met restriction reduces the activity of Akt and mitochondrial distribution of phosphorylated Raf and AIF, and increases mitochondrial Bak distribution. Tyr/Phe restriction reduces the amount of Bcl-2 protein and increases Bcl-XL mitochondrial distribution. Met restriction decreases mitochondrial distribution of Bcl-XL. In PC3, Met restriction induces apoptosis but this is not associated with alterations in intracellular distribution of Raf, Bcl-2 family proteins or AIF. All amino acid restrictions inhibited Akt activity. Supported by R01CA101035." @default.
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- W16185311 date "2006-03-01" @default.
- W16185311 modified "2023-10-16" @default.
- W16185311 title "Specific Amino Acid Dependency Regulates Multiple Pathways Controlling Invasiveness and Apoptosis of Prostate Cancer Cells" @default.
- W16185311 doi "https://doi.org/10.1096/fasebj.20.5.a1011-c" @default.
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