FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1618742753> ?p ?o ?g. }

• W1618742753 endingPage "1219" @default.
• W1618742753 startingPage "1212" @default.
• W1618742753 abstract "To determine whether or not flow-cytometric evidence of aneuploidy and increased G2/tetraploid fractions predispose to neoplastic progression in Barrett's esophagus, 62 patients with Barrett's esophagus were evaluated prospectively for a mean interval of 34 months. Nine of 13 patients who showed aneuploid or increased G2/tetraploid populations in their initial flow-cytometric analysis developed high-grade dysplasia or adenocarcinoma during follow-up; none of the 49 patients without these abnormalities progressed to high-grade dysplasia or cancer (P less than 0.0001). Neoplastic progression was characterized by progressive flow-cytometric and histological abnormalities. Patients who progressed to high-grade dysplasia and carcinoma frequently developed multiple aneuploid populations of cells that were detectable flow-cytometrically. Similarly, patients appeared to progress through a phenotypic sequence that could be recognized histologically by the successive appearance of Barrett's metaplasia negative for dysplasia, abnormalities in the indefinite/low-grade dysplasia range, high-grade dysplasia, and eventually adenocarcinoma. These and prior results suggest that neoplastic progression in Barrett's esophagus occurs in a subset of patients who have an acquired genomic instability that generates abnormal clones of cells, some of which have aneuploid or increased G2/tetraploid DNA contents. With continued genomic instability, multiple aneuploid subclones may evolve, one of which may ultimately acquire the ability to invade and become an early carcinoma. The combination of histology and flow cytometry can be used to identify a subset of patients with Barrett's esophagus who merit more frequent endoscopic surveillance for the early detection of high-grade dysplasia or carcinoma." @default.
• W1618742753 created "2016-06-24" @default.
• W1618742753 creator A5009322004 @default.
• W1618742753 creator A5023218961 @default.
• W1618742753 creator A5025406097 @default.
• W1618742753 creator A5057244007 @default.
• W1618742753 creator A5059964281 @default.
• W1618742753 creator A5087750564 @default.
• W1618742753 date "1992-04-01" @default.
• W1618742753 modified "2023-10-12" @default.
• W1618742753 title "Flow-cytometric and histological progression to malignancy in Barrett's esophagus: Prospective endoscopic surveillance of a cohort" @default.
• W1618742753 cites W1514032394 @default.
• W1618742753 cites W1521690089 @default.
• W1618742753 cites W1535526595 @default.
• W1618742753 cites W1822575538 @default.
• W1618742753 cites W1824572340 @default.
• W1618742753 cites W186917364 @default.
• W1618742753 cites W1905723718 @default.
• W1618742753 cites W1972955523 @default.
• W1618742753 cites W1980847511 @default.
• W1618742753 cites W1982061874 @default.
• W1618742753 cites W2004008931 @default.
• W1618742753 cites W2007615021 @default.
• W1618742753 cites W2008695752 @default.
• W1618742753 cites W2023325379 @default.
• W1618742753 cites W2031756765 @default.
• W1618742753 cites W2059432966 @default.
• W1618742753 cites W2085679251 @default.
• W1618742753 cites W2095256813 @default.
• W1618742753 cites W2415856308 @default.
• W1618742753 cites W2463984835 @default.
• W1618742753 cites W4231986221 @default.
• W1618742753 doi "https://doi.org/10.1016/0016-5085(92)90758-q" @default.
• W1618742753 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1551528" @default.
• W1618742753 hasPublicationYear "1992" @default.
• W1618742753 type Work @default.
• W1618742753 sameAs 1618742753 @default.
• W1618742753 citedByCount "437" @default.
• W1618742753 countsByYear W16187427532012 @default.
• W1618742753 countsByYear W16187427532013 @default.
• W1618742753 countsByYear W16187427532014 @default.
• W1618742753 countsByYear W16187427532015 @default.
• W1618742753 countsByYear W16187427532016 @default.
• W1618742753 countsByYear W16187427532017 @default.
• W1618742753 countsByYear W16187427532018 @default.
• W1618742753 countsByYear W16187427532019 @default.
• W1618742753 countsByYear W16187427532020 @default.
• W1618742753 countsByYear W16187427532021 @default.
• W1618742753 countsByYear W16187427532022 @default.
• W1618742753 countsByYear W16187427532023 @default.
• W1618742753 crossrefType "journal-article" @default.
• W1618742753 hasAuthorship W1618742753A5009322004 @default.
• W1618742753 hasAuthorship W1618742753A5023218961 @default.
• W1618742753 hasAuthorship W1618742753A5025406097 @default.
• W1618742753 hasAuthorship W1618742753A5057244007 @default.
• W1618742753 hasAuthorship W1618742753A5059964281 @default.
• W1618742753 hasAuthorship W1618742753A5087750564 @default.
• W1618742753 hasBestOaLocation W16187427531 @default.
• W1618742753 hasConcept C104317684 @default.
• W1618742753 hasConcept C121608353 @default.
• W1618742753 hasConcept C126322002 @default.
• W1618742753 hasConcept C142724271 @default.
• W1618742753 hasConcept C2775894508 @default.
• W1618742753 hasConcept C2776497702 @default.
• W1618742753 hasConcept C2777819096 @default.
• W1618742753 hasConcept C2778589982 @default.
• W1618742753 hasConcept C2779357193 @default.
• W1618742753 hasConcept C2779399171 @default.
• W1618742753 hasConcept C2779672484 @default.
• W1618742753 hasConcept C2780323790 @default.
• W1618742753 hasConcept C2781182431 @default.
• W1618742753 hasConcept C30481170 @default.
• W1618742753 hasConcept C54355233 @default.
• W1618742753 hasConcept C57742111 @default.
• W1618742753 hasConcept C71924100 @default.
• W1618742753 hasConcept C86803240 @default.
• W1618742753 hasConcept C90924648 @default.
• W1618742753 hasConceptScore W1618742753C104317684 @default.
• W1618742753 hasConceptScore W1618742753C121608353 @default.
• W1618742753 hasConceptScore W1618742753C126322002 @default.
• W1618742753 hasConceptScore W1618742753C142724271 @default.
• W1618742753 hasConceptScore W1618742753C2775894508 @default.
• W1618742753 hasConceptScore W1618742753C2776497702 @default.
• W1618742753 hasConceptScore W1618742753C2777819096 @default.
• W1618742753 hasConceptScore W1618742753C2778589982 @default.
• W1618742753 hasConceptScore W1618742753C2779357193 @default.
• W1618742753 hasConceptScore W1618742753C2779399171 @default.
• W1618742753 hasConceptScore W1618742753C2779672484 @default.
• W1618742753 hasConceptScore W1618742753C2780323790 @default.
• W1618742753 hasConceptScore W1618742753C2781182431 @default.
• W1618742753 hasConceptScore W1618742753C30481170 @default.
• W1618742753 hasConceptScore W1618742753C54355233 @default.
• W1618742753 hasConceptScore W1618742753C57742111 @default.
• W1618742753 hasConceptScore W1618742753C71924100 @default.
• W1618742753 hasConceptScore W1618742753C86803240 @default.
• W1618742753 hasConceptScore W1618742753C90924648 @default.
• W1618742753 hasIssue "4" @default.
• W1618742753 hasLocation W16187427531 @default.

• next