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• W161905245 startingPage "1706" @default.
• W161905245 abstract "To evaluate the long-term histological outcome of patients transplanted for HBV-related liver disease and given HBIg prophylaxis indefinitely after LT.Forty-two consecutive patients transplanted for hepatitis B were prospectively studied. HBsAg, HBV-DNA and liver function tests were evaluated in the serum 3, 6 and 12 mo after LT and then yearly. LB was obtained 6 and 12 mo after LT and yearly thereafter. Chronic hepatitis (CH) B after LT was classified as minimal, mild, moderate or severe.HBV recurred in 7/42 (16.6%) patients after 6-96 mo of follow-up. A hundred and eighty-seven LB were evaluated. Four of 7 patients with graft reinfection, all with unknown HBV DNA status before LT, developed cirrhosis at 12-36 mo of follow-up. Of the 122 LB obtained from 28 HBsAg+/HCV- recipients with no HBV recurrence after LT, all biopsies were completely normal in only 2 patients (7.1%), minimal/non-specific changes were observed in 18 (64.2%), and at least 1 biopsy showed CH in the remaining 8 (28.5%). Twenty-nine LB obtained from 7 patients transplanted for HBV-HCV cirrhosis and remaining HBsAg- after LT revealed recurrent CH-C. Actuarial survival was similar in patients with HBsAg+ or HBsAg- liver diseases.Though protocol biopsies may enable the detection of graft dysfunction at an early stage, the risk of progression and the clinical significance of these findings remains to be determined." @default.
• W161905245 created "2016-06-24" @default.
• W161905245 creator A5001685123 @default.
• W161905245 date "2006-01-01" @default.
• W161905245 modified "2023-10-16" @default.
• W161905245 title "Protocol liver biopsies in long-term management of patients transplanted for hepatitis B-related liver disease" @default.
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• W161905245 doi "https://doi.org/10.3748/wjg.v12.i11.1706" @default.
• W161905245 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4124344" @default.
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• W161905245 hasPublicationYear "2006" @default.
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