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- W1619083503 abstract "This chapter discusses the control of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion. The concept of neurohormonal control of adenohypophysial function can be translated into precise biochemical and chemical terms. Although the influence of the hypothalamus on the secretion of both gonadotropins is probably exerted exclusively through LHRH, it is well recognized that gonadal steroids can have a marked influence on LH and FSH secretion. In vivo treatment with estrogens is well known to lead to a stimulation of prolactin secretion in both man and rat. The stimulation of hormonal secretion by estradiol induces significant changes of the cell surface morphology, indicating a good correlation between secretion and modification of cell surface. Rat anterior pituitary cells in culture, which have previously been shown to be highly precise, sensitive, and valid assay systems for LHRH, TRH, somatostatin, and dopamine analogs, can also be advantageously used as a screening assay for glucocorticoid agonists and antagonists." @default.
- W1619083503 created "2016-06-24" @default.
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- W1619083503 date "1983-01-01" @default.
- W1619083503 modified "2023-10-05" @default.
- W1619083503 title "Anterior Pituitary Cells in Culture: A Precise Assay System for Hypothalamic and Peripheral Hormones" @default.
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- W1619083503 doi "https://doi.org/10.1016/b978-0-12-008304-6.50018-x" @default.
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