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• W1619363677 abstract "Methadone is a synthetic opioid usually used as a maintenance therapy for heroin dependence [ [1] Ng M.H. Chou J.Y. Chang T.J. Lee P.C. Shao W.C. Lin T.Y. et al. High prevalence but low awareness of hepatitis C virus infection among heroin users who received methadone maintenance therapy in Taiwan. Addict. Behav. 2013; 38: 2089-2093 Crossref PubMed Scopus (23) Google Scholar ]. It has been reported that the infection rates with human immunodeficiency virus (HIV) and/or hepatitis C virus (HCV) were higher in patients undergoing methadone maintenance treatment (MMT) [ [2] Zhuang X. Wang Y. Chow E.P. Liang Y. Wilson D.P. Zhang L. Risk factors associated with HIV/HCV infection among entrants in methadone maintenance treatment clinics in China: a systematic review and meta-analysis. Drug Alcohol Depend. 2012; 126: 286-295 Abstract Full Text Full Text PDF PubMed Scopus (27) Google Scholar ]. However, the influence of co-infection with HIV and HCV on the treatment responses to methadone has yet to be studied. A higher plasma level of chemokine interferon gamma-inducible protein 10 (IP-10, also called chemokine (C-X-C motif) ligand 10, CXCL 10) has been reported in patients infected with both HIV and HCV than those infected with only single virus [ [3] Roe B. Coughlan S. Hassan J. Grogan A. Farrell G. Norris S. et al. Elevated serum levels of interferon-gamma-inducible protein-10 in patients coinfected with hepatitis C virus and HIV. J. Infect. Dis. 2007; 196: 1053-1057 Crossref PubMed Scopus (61) Google Scholar ]. Increased expression of IP-10, CXCR3 receptors in the CD8(+) lymphocytes has also been reported in patients co-infected with HIV and HCV [ [4] Kimball P. McDougan F. Stirling R. CXCR3 expression elevated on peripheral CD8(+) lymphocytes from HIV/HCV coinfected individuals. Viral Immunol. 2011; 24: 441-448 Crossref PubMed Scopus (6) Google Scholar ]. Furthermore, IP-10 has been suggested as a biomarker for predicting the HCV treatment outcome for patients infected with both HIV and HCV [ [5] Zeremski M. Markatou M. Brown Q.B. Dorante G. Cunningham-Rundles S. Talal A.H. Interferon gamma-inducible protein 10: a predictive marker of successful treatment response in hepatitis C virus/HIV-coinfected patients. J. Acquir. Immune Defic. Syndr. 2007; 45: 262-268 PubMed Google Scholar ]. However, the influence of chemokines/cytokines on the treatment responses to methadone and HIV/HCV infection remains unclear." @default.
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• W1619363677 date "2015-09-01" @default.
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• W1619363677 title "Chemokine IP-10 is correlated with cardiac responses and status of infection with HIV and HCV in methadone maintenance patients" @default.
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• W1619363677 doi "https://doi.org/10.1016/j.ijcard.2015.05.055" @default.
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