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- W1619637323 abstract "Autosomal-Dominant-Polycystic-Kidney-Disease type-II (ADPKD-II) is caused by mutations in the Polycystin-2 (PC2) encoding gene. The dysfunction of this Ca2+-conducting channel leads to the formation of fluid-filled renal cysts (1). Through poorly known mechanisms, cystogenesis entails an overstimulation of Cystic-Fibrosis-Transmembrane-conductance-Regulator (CFTR), a key Cl--channel in epithelia's ion/fluid transport (2). To study PC2-CFTR crosstalk we used the zebrafish embryonic node (Kupffer's Vesicle, KV) as a model system. Both proteins are required for KV proper function (3,4)." @default.
- W1619637323 created "2016-06-24" @default.
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- W1619637323 date "2015-07-13" @default.
- W1619637323 modified "2023-09-26" @default.
- W1619637323 title "Identification of Polycystin-2 and CFTR common targets" @default.
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- W1619637323 doi "https://doi.org/10.1186/2046-2530-4-s1-p4" @default.
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