FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1620218395> ?p ?o ?g. }

• W1620218395 endingPage "3235" @default.
• W1620218395 startingPage "3229" @default.
• W1620218395 abstract "Abstract CTL and NK cells use two distinct cytocidal pathways: 1) perforin and granzyme based and 2) CD95L/CD95 mediated. The former requires perforin expression by the effectors (CTL or NK), whereas the latter requires CD95 (Fas/APO-1) expression by the target. We have investigated how these two factors contribute to tumor immune surveillance by studying the immunity of perforin-deficient mice against the progressor C57BL/6 Lewis lung carcinoma 3LL, which expresses no CD95 when cultured in vitro. Unexpectedly, the results indicated that the perforin-independent CD95L/CD95 pathway of CTL/NK plays a role in acting against D122 and Kb39.5 (39.5) high and low metastatic sublines, respectively, derived from the 3LL tumor. Although no membrane-bound CD95 was detected on cultured D122 and 39.5 cells, surface CD95 expression on both D122 and 39.5 was considerably up-regulated when the tumors were grown in vivo. A similarly enhanced expression of CD95 was observed with three additional tumors; LF−, BW, and P815, injected into syngeneic and allogeneic mice. The finding of up-regulated CD95 expression on tumor cells placed in vivo suggests that a CD95-based mechanism plays a role in tumor immunity at early stages of tumor growth. Consequently, the progressive down-regulation of CD95 expression during tumor progression may indeed be an escape mechanism as previously reported. Together, these results suggest a role for CD95-dependent, perforin-independent immunity against certain tumors." @default.
• W1620218395 created "2016-06-24" @default.
• W1620218395 creator A5001441814 @default.
• W1620218395 creator A5008655303 @default.
• W1620218395 creator A5052562670 @default.
• W1620218395 creator A5053650058 @default.
• W1620218395 creator A5063663265 @default.
• W1620218395 creator A5090003736 @default.
• W1620218395 date "2000-03-15" @default.
• W1620218395 modified "2023-10-17" @default.
• W1620218395 title "Tumor Immunity in Perforin-Deficient Mice: A Role for CD95 (Fas/APO-1)" @default.
• W1620218395 cites W1560589934 @default.
• W1620218395 cites W1581932048 @default.
• W1620218395 cites W1772617136 @default.
• W1620218395 cites W1967690365 @default.
• W1620218395 cites W1989600187 @default.
• W1620218395 cites W2002503549 @default.
• W1620218395 cites W2008890570 @default.
• W1620218395 cites W2016198585 @default.
• W1620218395 cites W2034367373 @default.
• W1620218395 cites W2041466047 @default.
• W1620218395 cites W2045796964 @default.
• W1620218395 cites W2048773810 @default.
• W1620218395 cites W2049873918 @default.
• W1620218395 cites W2053508680 @default.
• W1620218395 cites W2054291992 @default.
• W1620218395 cites W2064706357 @default.
• W1620218395 cites W2068324509 @default.
• W1620218395 cites W2075579683 @default.
• W1620218395 cites W2082173837 @default.
• W1620218395 cites W2088137443 @default.
• W1620218395 cites W2091720585 @default.
• W1620218395 cites W2109721791 @default.
• W1620218395 cites W2111181668 @default.
• W1620218395 cites W2116293732 @default.
• W1620218395 cites W2132236006 @default.
• W1620218395 cites W2137478600 @default.
• W1620218395 cites W2145745694 @default.
• W1620218395 cites W2149944442 @default.
• W1620218395 cites W2162002002 @default.
• W1620218395 cites W2165343206 @default.
• W1620218395 cites W2179862924 @default.
• W1620218395 cites W2278523282 @default.
• W1620218395 cites W4322385172 @default.
• W1620218395 doi "https://doi.org/10.4049/jimmunol.164.6.3229" @default.
• W1620218395 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10706715" @default.
• W1620218395 hasPublicationYear "2000" @default.
• W1620218395 type Work @default.
• W1620218395 sameAs 1620218395 @default.
• W1620218395 citedByCount "57" @default.
• W1620218395 countsByYear W16202183952012 @default.
• W1620218395 countsByYear W16202183952014 @default.
• W1620218395 countsByYear W16202183952016 @default.
• W1620218395 countsByYear W16202183952019 @default.
• W1620218395 countsByYear W16202183952020 @default.
• W1620218395 countsByYear W16202183952022 @default.
• W1620218395 crossrefType "journal-article" @default.
• W1620218395 hasAuthorship W1620218395A5001441814 @default.
• W1620218395 hasAuthorship W1620218395A5008655303 @default.
• W1620218395 hasAuthorship W1620218395A5052562670 @default.
• W1620218395 hasAuthorship W1620218395A5053650058 @default.
• W1620218395 hasAuthorship W1620218395A5063663265 @default.
• W1620218395 hasAuthorship W1620218395A5090003736 @default.
• W1620218395 hasBestOaLocation W16202183951 @default.
• W1620218395 hasConcept C147969180 @default.
• W1620218395 hasConcept C150903083 @default.
• W1620218395 hasConcept C167672396 @default.
• W1620218395 hasConcept C183193105 @default.
• W1620218395 hasConcept C190283241 @default.
• W1620218395 hasConcept C203014093 @default.
• W1620218395 hasConcept C207001950 @default.
• W1620218395 hasConcept C2776062744 @default.
• W1620218395 hasConcept C2779341262 @default.
• W1620218395 hasConcept C2780380082 @default.
• W1620218395 hasConcept C3031857 @default.
• W1620218395 hasConcept C31573885 @default.
• W1620218395 hasConcept C502942594 @default.
• W1620218395 hasConcept C55493867 @default.
• W1620218395 hasConcept C86803240 @default.
• W1620218395 hasConcept C8891405 @default.
• W1620218395 hasConceptScore W1620218395C147969180 @default.
• W1620218395 hasConceptScore W1620218395C150903083 @default.
• W1620218395 hasConceptScore W1620218395C167672396 @default.
• W1620218395 hasConceptScore W1620218395C183193105 @default.
• W1620218395 hasConceptScore W1620218395C190283241 @default.
• W1620218395 hasConceptScore W1620218395C203014093 @default.
• W1620218395 hasConceptScore W1620218395C207001950 @default.
• W1620218395 hasConceptScore W1620218395C2776062744 @default.
• W1620218395 hasConceptScore W1620218395C2779341262 @default.
• W1620218395 hasConceptScore W1620218395C2780380082 @default.
• W1620218395 hasConceptScore W1620218395C3031857 @default.
• W1620218395 hasConceptScore W1620218395C31573885 @default.
• W1620218395 hasConceptScore W1620218395C502942594 @default.
• W1620218395 hasConceptScore W1620218395C55493867 @default.
• W1620218395 hasConceptScore W1620218395C86803240 @default.
• W1620218395 hasConceptScore W1620218395C8891405 @default.
• W1620218395 hasIssue "6" @default.
• W1620218395 hasLocation W16202183951 @default.

• next