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• W1620223359 abstract "Although a variety of chemical syntheses for the epothilones and various derivatives have been described, modifying the backbone of those natural products remains a major challenge. One alternative to chemical alteration is the elucidation and subsequent manipulation of the biosynthetic pathway via genetic engineering in the producing organism. This type of approach is known as “combinatorial biosynthesis” and holds great promise, especially in conjunction with semi-synthesis methods to alter the structure of the natural product. In parallel, production can be optimized in the natural producer if the regulatory mechanisms governing the biosynthesis are understood. Alternatively, the entire gene cluster can be transferred into a heterologous host, more amenable both to genetic alteration and overexpression." @default.
• W1620223359 created "2016-06-24" @default.
• W1620223359 creator A5077818118 @default.
• W1620223359 date "2009-01-01" @default.
• W1620223359 modified "2023-09-26" @default.
• W1620223359 title "Biosynthesis and Heterologous Production of Epothilones" @default.
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• W1620223359 doi "https://doi.org/10.1007/978-3-211-78207-1_2" @default.
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