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- W1621023898 abstract "Despite optimal treatment with antipsychotics, most patients with schizophrenia persist with severe functional impairment and poor quality of life [ [1] Zugman A. Gadelha A. Assunção I. et al. Reduced dorso-lateral prefrontal cortex in treatment resistant schizophrenia. Schizophr Res. 2013; 148: 81-86https://doi.org/10.1016/j.schres.2013.05.002 Abstract Full Text Full Text PDF PubMed Scopus (36) Google Scholar ]. Negative symptoms are among the major determinants of such functional impairment and have no specific treatment [ [2] Carbon M. Correll C.U. Thinking and acting beyond the positive: the role of the cognitive and negative symptoms in schizophrenia. CNS Spectr. 2014; 19: 35-53http://dx.doi.org/10.1017/S1092852914000601 Crossref Scopus (112) Google Scholar ]. In a recent study, Fervaha and collaborators showed that motivational deficits were present in more than 75% of a cohort of young patients (18–35 years). According to the authors, these deficits – which are at the core of negative symptoms – are manifested earlier in the disease's course then generally assumed, and impose one of the main challenges of the field as a whole [ [3] Fervaha G. Foussias G. Agid O. Remington G. Motivational deficits in early schizophrenia: prevalent, persistent, and key determinants of functional outcome. Schizophr Res. 2015; https://doi.org/10.1016/j.schres.2015.04.040 Abstract Full Text Full Text PDF Scopus (95) Google Scholar ]." @default.
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- W1621023898 date "2015-09-01" @default.
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- W1621023898 title "Left Dorsolateral Prefrontal Cortex Anodal tDCS Effects on Negative Symptoms in Schizophrenia" @default.
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- W1621023898 doi "https://doi.org/10.1016/j.brs.2015.07.033" @default.
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