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- W162113137 abstract "SummaryThe clinical, biochemical and histological characteristics in six Arab children with progressive familial intrahepatic cholestasis (PFIC) (Byler's disease) are described. The autosomal recessive mode of inheritance is established. Jaundice and pruritus were early symptoms, with onset in the 1st 3 months in all patients. Other features included growth failure, developmental delay, ataxia, areflexia, gall-stones and epistaxis. Gamma-glutamyl-transpeptidase and cholesterol were normal, but total bile acid levels were uniformly elevated in all patients. Histology showed features of hepato-canalicular cholestasis, lack of bile duct proliferation and fibrosis or cirrhosis in all patients. Five patients who were followed up were alive at a mean age of 75.8 months." @default.
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- W162113137 date "1995-12-01" @default.
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- W162113137 title "Progressive familial intrahepatic cholestasis (Byler's disease) in Arab children" @default.
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- W162113137 doi "https://doi.org/10.1080/02724936.1995.11747792" @default.
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