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• W1621335451 endingPage "847" @default.
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• W1621335451 abstract "The microbiological inventory of spacecraft and the associated assembly facility surfaces represent the primary pool of forward contaminants that may impact the integrity of life-detection missions. Herein, we report on the characterization of several strains of hydrogen peroxide–resistant Acinetobacter, which were isolated during the Mars Phoenix lander assembly. All Phoenix-associated Acinetobacter strains possessed very high catalase specific activities, and the specific strain, A. gyllenbergii 2P01AA, displayed a survival against hydrogen peroxide (no loss in 100 mM H2O2 for 1 h) that is perhaps the highest known among Gram-negative and non-spore-forming bacteria. Proteomic characterizations reveal a survival mechanism inclusive of proteins coupled to peroxide degradation (catalase and alkyl hydroperoxide reductase), energy/redox management (dihydrolipoamide dehydrogenase), protein synthesis/folding (EF-G, EF-Ts, peptidyl-tRNA hydrolase, DnaK), membrane functions (OmpA-like protein and ABC transporter–related protein), and nucleotide metabolism (HIT family hydrolase). Together, these survivability and biochemical parameters support the hypothesis that oxidative tolerance and the related biochemical features are the measurable phenotypes or outcomes for microbial survival in the spacecraft assembly facilities, where the low-humidity (desiccation) and clean (low-nutrient) conditions may serve as selective pressures. Hence, the spacecraft-associated Acinetobacter, due to the conferred oxidative tolerances, may ultimately hinder efforts to reduce spacecraft bioburden when using chemical sterilants, thus suggesting that non-spore-forming bacteria may need to be included in the bioburden accounting for future life-detection missions. Key Words: Extremophiles—Planetary protection—Spacecraft assembly facility—Stress proteins—Microbe. Astrobiology 14, 837–847." @default.
• W1621335451 created "2016-06-24" @default.
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• W1621335451 date "2014-10-01" @default.
• W1621335451 modified "2023-10-01" @default.
• W1621335451 title "Characterization of Hydrogen Peroxide–Resistant<i>Acinetobacter</i>Species Isolated during the Mars Phoenix Spacecraft Assembly" @default.
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• W1621335451 doi "https://doi.org/10.1089/ast.2014.1193" @default.
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