Matches in SemOpenAlex for { <https://semopenalex.org/work/W1621386139> ?p ?o ?g. }
- W1621386139 endingPage "11980" @default.
- W1621386139 startingPage "11959" @default.
- W1621386139 abstract "Aptamers and SELEX (systematic evolution of ligands by exponential enrichment) technology have gained increasing attention over the past 25 years. Despite their functional similarity to protein antibodies, oligonucleotide aptamers have many unique properties that are suitable for clinical applications and industrialization. Aptamers may be superior to antibodies in fields such as biomarker discovery, in vitro and in vivo diagnosis, precisely controlled drug release, and targeted therapy. However, aptamer commercialization has not occurred as quickly as expected, and few aptamer-based products have yet successfully entered clinical and industrial use. Thus, it is important to critically review some technical barriers of aptamer and SELEX technology per se that may impede aptamer development and application. To date, how to rapidly obtain aptamers with superior bioavailability over antibodies remains the key issue. In this review, we discuss different chemical and structural modification strategies aimed to enhance aptamer bioavailability. We also discuss improvements to SELEX process steps to shorten the selection period and improve the SELEX process success rate. Applications in which aptamers are particularly suited and perform differently or superior to antibodies are briefly introduced." @default.
- W1621386139 created "2016-06-24" @default.
- W1621386139 creator A5040710006 @default.
- W1621386139 creator A5064786948 @default.
- W1621386139 date "2015-06-30" @default.
- W1621386139 modified "2023-10-16" @default.
- W1621386139 title "A Highlight of Recent Advances in Aptamer Technology and Its Application" @default.
- W1621386139 cites W1573786554 @default.
- W1621386139 cites W1757682296 @default.
- W1621386139 cites W1912230311 @default.
- W1621386139 cites W1941658307 @default.
- W1621386139 cites W1963858708 @default.
- W1621386139 cites W1967833179 @default.
- W1621386139 cites W1974506413 @default.
- W1621386139 cites W1975391225 @default.
- W1621386139 cites W1976531401 @default.
- W1621386139 cites W1979114856 @default.
- W1621386139 cites W1980133334 @default.
- W1621386139 cites W1980585134 @default.
- W1621386139 cites W1981322588 @default.
- W1621386139 cites W1981942089 @default.
- W1621386139 cites W1983236663 @default.
- W1621386139 cites W1985290031 @default.
- W1621386139 cites W1990046017 @default.
- W1621386139 cites W1991867442 @default.
- W1621386139 cites W1993259011 @default.
- W1621386139 cites W1995242885 @default.
- W1621386139 cites W1995319717 @default.
- W1621386139 cites W1996517412 @default.
- W1621386139 cites W2001401934 @default.
- W1621386139 cites W2002089022 @default.
- W1621386139 cites W2003418160 @default.
- W1621386139 cites W2003711915 @default.
- W1621386139 cites W2006810649 @default.
- W1621386139 cites W2008550028 @default.
- W1621386139 cites W2008819279 @default.
- W1621386139 cites W2010120270 @default.
- W1621386139 cites W2011800982 @default.
- W1621386139 cites W2014909608 @default.
- W1621386139 cites W2017296058 @default.
- W1621386139 cites W2023373190 @default.
- W1621386139 cites W2023966429 @default.
- W1621386139 cites W2024682947 @default.
- W1621386139 cites W2027246775 @default.
- W1621386139 cites W2029760928 @default.
- W1621386139 cites W2030716187 @default.
- W1621386139 cites W2031580508 @default.
- W1621386139 cites W2038551857 @default.
- W1621386139 cites W2038730459 @default.
- W1621386139 cites W2040273699 @default.
- W1621386139 cites W2041252239 @default.
- W1621386139 cites W2042052317 @default.
- W1621386139 cites W2044045359 @default.
- W1621386139 cites W2044601776 @default.
- W1621386139 cites W2045143882 @default.
- W1621386139 cites W2045654913 @default.
- W1621386139 cites W2045974535 @default.
- W1621386139 cites W2046391187 @default.
- W1621386139 cites W2047088479 @default.
- W1621386139 cites W2047103966 @default.
- W1621386139 cites W2048325608 @default.
- W1621386139 cites W2048739025 @default.
- W1621386139 cites W2050051050 @default.
- W1621386139 cites W2050188654 @default.
- W1621386139 cites W2051620208 @default.
- W1621386139 cites W2051648173 @default.
- W1621386139 cites W2053662322 @default.
- W1621386139 cites W2054703112 @default.
- W1621386139 cites W2054753693 @default.
- W1621386139 cites W2055119381 @default.
- W1621386139 cites W2055445480 @default.
- W1621386139 cites W2056285082 @default.
- W1621386139 cites W2057271684 @default.
- W1621386139 cites W2059281433 @default.
- W1621386139 cites W2059346730 @default.
- W1621386139 cites W2063028257 @default.
- W1621386139 cites W2064157091 @default.
- W1621386139 cites W2064809498 @default.
- W1621386139 cites W2066074720 @default.
- W1621386139 cites W2068090911 @default.
- W1621386139 cites W2069649187 @default.
- W1621386139 cites W2071776168 @default.
- W1621386139 cites W2073540937 @default.
- W1621386139 cites W2074988418 @default.
- W1621386139 cites W2077779605 @default.
- W1621386139 cites W2078520385 @default.
- W1621386139 cites W2079321730 @default.
- W1621386139 cites W2080567946 @default.
- W1621386139 cites W2081136588 @default.
- W1621386139 cites W2084373725 @default.
- W1621386139 cites W2086047273 @default.
- W1621386139 cites W2086841148 @default.
- W1621386139 cites W2088628587 @default.
- W1621386139 cites W2089397494 @default.
- W1621386139 cites W2090104316 @default.
- W1621386139 cites W2095720741 @default.
- W1621386139 cites W2096617035 @default.
- W1621386139 cites W2100993561 @default.