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- W1621394 abstract "The synaptic localization of α-internexin, a brain-specific intermediate filament protein, was investigated immunohistochemically in the rat brain. The specificity of the antibody used in this study was confirmed by Western blotting and the antibody specifically reacted with α-internexin in the neurofilament preparation and in the postsynaptic density (PSD) fraction. The α-internexin immunoreactivity was distributed in neurons, especially in the somata and dendrites, throughout the cerebral cortex. Immunoelectron microscopic examination showed the immunoreactivity in the PSD, while neurofilament M was not in the PSD. Thus α-internexin and neurofilament M are differentially localized in neuronal cells. α-Internexin content in the PSD fraction was relatively high even before the period of synaptogenesis and the content in the fraction was unchanged between young and adult rats (2–6 weeks old). These results suggest a role of α-internexin for early development and organization of the PSD." @default.
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- W1621394 date "1997-08-01" @default.
- W1621394 modified "2023-10-16" @default.
- W1621394 title "Excitable membranes and synaptic transmission: postsynaptic mechanisms." @default.
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- W1621394 doi "https://doi.org/10.1016/s0006-8993(97)00492-7" @default.
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