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• W1621770919 abstract "Recent evidence indicates that sphingolipids are produced by the heart during hypoxic stress and by blood platelets during thrombus formation. It is therefore possible that sphingolipids may influence heart cell function by interacting with G‐protein‐coupled receptors of the Edg family. In the present study, it was found that sphingosine 1‐phosphate (Sph1 P ), the prototypical ligand for Edg receptors, produced calcium overload in rat cardiomyocytes. The cDNA for Edg‐1 was cloned from rat cardiomyocytes and, when transfected in an antisense orientation, effectively blocked Edg‐1 protein expression and reduced the Sph1 P ‐mediated calcium deregulation. Taken together, these results demonstrate that cardiomyocytes express an extracellular lipid‐sensitive receptorsystem that can respond to sphingolipid mediators. Because the major source of Sph1 P is from blood platelets, we speculate that Edg‐mediated Sph1 P negative inotropic and cardiotoxic effects may play important roles in acute myocardial ischemia where Sph1 P levels are probably elevated in response to thrombus." @default.
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• W1621770919 date "2000-09-01" @default.
• W1621770919 modified "2023-10-18" @default.
• W1621770919 title "Expression and characterization of Edg-1 receptors in rat cardiomyocytes" @default.
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• W1621770919 doi "https://doi.org/10.1046/j.1432-1327.2000.01656.x" @default.
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