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• W1622499031 endingPage "54" @default.
• W1622499031 startingPage "37" @default.
• W1622499031 abstract "The detection of volatile chemical information in insects is performed by three types of olfactory receptors, odorant receptors (ORs), specific gustatory receptor (GR) proteins for carbon dioxide perception, and ionotropic receptors (IRs) which are related to ionotropic glutamate receptors. All receptors form heteromeric assemblies; an OR complex is composed of an odor-specific OrX protein and a coreceptor (Orco). ORs and GRs have a 7-transmembrane topology as for G protein-coupled receptors, but they are inversely inserted into the membrane. Ligand-gated ion channels (ionotropic receptors) and ORs operate as IRs activated by volatile chemical cues. ORs are evolutionarily young receptors, and they first appear in winged insects and seem to be evolved to allow an insect to follow sparse odor tracks during flight. In contrast to IRs, the ORs can be sensitized by repeated subthreshold odor stimulation. This process involves metabotropic signaling. Pheromone receptors are especially sensitive and require an accessory protein to detect the lipid-derived pheromone molecules. Signaling cascades involved in pheromone detection depend on intensity and duration of stimuli and underlie a circadian control. Taken together, detection and processing of volatile information in insects involve ionotropic as well as metabotropic mechanisms. Here, I review the cellular signaling events associated with detection of cognate ligands by the different types of odorant receptors." @default.
• W1622499031 created "2016-06-24" @default.
• W1622499031 creator A5031767592 @default.
• W1622499031 date "2015-01-01" @default.
• W1622499031 modified "2023-09-28" @default.
• W1622499031 title "Olfactory Signaling in Insects" @default.
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• W1622499031 doi "https://doi.org/10.1016/bs.pmbts.2014.11.002" @default.
• W1622499031 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25623336" @default.
• W1622499031 hasPublicationYear "2015" @default.
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