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- W1622758468 abstract "This chapter describes an alternative method for identifying pathogen virulence factors that is based on the finding that many mammalian pathogens are also capable of causing disease in simple nonvertebrate hosts. The ability of Pseudomonas aeruginosa to infect plants as well as animals was subsequently extended to show that the same clinical isolate of P. aeruginosa that can infect Arabidopsis, strain PA14, was also a pathogen of the nematode worm Caenorhabditis elegans as well as the insects Drosophila melanogaster and Galleria mellonella. Toxin-mediated killing is characterized by rapid worm killing, usually within one day, and by the ability of the conditioned media to kill in the absence of live bacteria. Infection-associated killing usually occurs over the course of several days and thus far has been characterized by the accumulation and, in some cases, proliferation of bacteria within the worm digestive tract. Drosophila is an ideal insect host for genetic analysis of the host innate immune response. However, as Drosophila is relatively small, it is difficult to inject bacteria directly into the body cavity. An alternative approach for investigating the function of microbial products that manipulate host cells is to express these bacterial toxins within a genetically tractable host system. Interactive genetic analysis was also used to define the role of P-glycoproteins (PGP) in protecting C. elegans from the toxic effects of phenazines." @default.
- W1622758468 created "2016-06-24" @default.
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- W1622758468 date "2014-04-30" @default.
- W1622758468 modified "2023-09-24" @default.
- W1622758468 title "Use of Simple Nonvertebrate Hosts To Model Mammalian Pathogenesis" @default.
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- W1622758468 doi "https://doi.org/10.1128/9781555817633.ch23" @default.
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