FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1622904595> ?p ?o ?g. }

• W1622904595 endingPage "1505" @default.
• W1622904595 startingPage "1501" @default.
• W1622904595 abstract "Oral contraceptives (OC) contain an orally active estrogen in combination with an orally active synthetic progestin derived from 19-nortestosterone. OC have had an enormous positive impact on public health for the past three decades, and in the main, there has been a remarkably low incidence of troublesome side effects. Although estrogens are implicated in an increased incidence of breast and endometrial cancer, epidemiologic studies have not provided convincing evidence to support a direct correlation between OC use and an increase in breast cancer incidence. By contrast, OC do cause a decrease in the incidence of endometrial and ovarian carcinoma. During the past decade, several isolated reports have linked an increased incidence of breast cancer with the use of synthetic progestins. No mechanism for the proliferative potential of progestins has been offered. Therefore, the authors investigated this problem to formulate a hypothesis, based on laboratory data, that might be evaluated in populations at risk.The synthetic progestins (19-nortestosterone derivatives) chosen for the study were norethynodrel, norethindrone, norgestrel (levonorgestrel), and gestodene. These were compared with the actions of medroxyprogesterone acetate (MPA). To determine whether the progestins produced their effects via the ER, the cells were transfected with a chloramphenicol acetyl transferase (CAT) reporter gene containing an estrogen response element only activated by ER.The 19-nortestosterone derivatives all stimulated the growth of estrogen receptor (ER)-positive but not ER-negative breast cancer cells in culture. Antiestrogens, but not the antiprogestin mifepristone (also known as RU 486), inhibited progestin-stimulated cell proliferation. MPA did not stimulate cell proliferation. All the synthetic progestins that increased replication also activated CAT. Activation was blocked by antiestrogens but not by mifepristone; the synthetic progestin MPA was inactive.These studies provided direct evidence that some synthetic progestins exert estrogenic effects through the ER. The results demonstrated that progestins can have a dual effect on estrogen target tissues either to stimulate or differentiate cells. The results suggest that some beneficial estrogen-like effects could be produced by synthetic progestins (e.g., bone preservation), but epidemiologic studies of OC use should focus of the total estrogen content to establish whether some formulations place some groups of women at greater risk of having breast cancer." @default.
• W1622904595 created "2016-06-24" @default.
• W1622904595 creator A5024583181 @default.
• W1622904595 creator A5052874547 @default.
• W1622904595 creator A5077808714 @default.
• W1622904595 creator A5091110591 @default.
• W1622904595 date "1993-02-15" @default.
• W1622904595 modified "2023-10-14" @default.
• W1622904595 title "The estrogenic activity of synthetic progestins used in oral contraceptives" @default.
• W1622904595 cites W2036020649 @default.
• W1622904595 cites W2057700119 @default.
• W1622904595 cites W2060903877 @default.
• W1622904595 cites W2068733105 @default.
• W1622904595 cites W2070450154 @default.
• W1622904595 cites W2087607852 @default.
• W1622904595 cites W2131573699 @default.
• W1622904595 cites W2336953700 @default.
• W1622904595 doi "https://doi.org/10.1002/cncr.2820710415" @default.
• W1622904595 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8431886" @default.
• W1622904595 hasPublicationYear "1993" @default.
• W1622904595 type Work @default.
• W1622904595 sameAs 1622904595 @default.
• W1622904595 citedByCount "58" @default.
• W1622904595 countsByYear W16229045952012 @default.
• W1622904595 countsByYear W16229045952015 @default.
• W1622904595 countsByYear W16229045952019 @default.
• W1622904595 countsByYear W16229045952020 @default.
• W1622904595 countsByYear W16229045952021 @default.
• W1622904595 countsByYear W16229045952022 @default.
• W1622904595 countsByYear W16229045952023 @default.
• W1622904595 crossrefType "journal-article" @default.
• W1622904595 hasAuthorship W1622904595A5024583181 @default.
• W1622904595 hasAuthorship W1622904595A5052874547 @default.
• W1622904595 hasAuthorship W1622904595A5077808714 @default.
• W1622904595 hasAuthorship W1622904595A5091110591 @default.
• W1622904595 hasConcept C121608353 @default.
• W1622904595 hasConcept C126322002 @default.
• W1622904595 hasConcept C134018914 @default.
• W1622904595 hasConcept C2776306185 @default.
• W1622904595 hasConcept C2776607906 @default.
• W1622904595 hasConcept C2777088508 @default.
• W1622904595 hasConcept C2777164284 @default.
• W1622904595 hasConcept C2778239997 @default.
• W1622904595 hasConcept C2778826759 @default.
• W1622904595 hasConcept C2779076696 @default.
• W1622904595 hasConcept C2779234561 @default.
• W1622904595 hasConcept C2779441745 @default.
• W1622904595 hasConcept C2780186607 @default.
• W1622904595 hasConcept C2781039349 @default.
• W1622904595 hasConcept C2908647359 @default.
• W1622904595 hasConcept C2986740045 @default.
• W1622904595 hasConcept C2986817661 @default.
• W1622904595 hasConcept C530470458 @default.
• W1622904595 hasConcept C54355233 @default.
• W1622904595 hasConcept C71924100 @default.
• W1622904595 hasConcept C86803240 @default.
• W1622904595 hasConcept C99454951 @default.
• W1622904595 hasConceptScore W1622904595C121608353 @default.
• W1622904595 hasConceptScore W1622904595C126322002 @default.
• W1622904595 hasConceptScore W1622904595C134018914 @default.
• W1622904595 hasConceptScore W1622904595C2776306185 @default.
• W1622904595 hasConceptScore W1622904595C2776607906 @default.
• W1622904595 hasConceptScore W1622904595C2777088508 @default.
• W1622904595 hasConceptScore W1622904595C2777164284 @default.
• W1622904595 hasConceptScore W1622904595C2778239997 @default.
• W1622904595 hasConceptScore W1622904595C2778826759 @default.
• W1622904595 hasConceptScore W1622904595C2779076696 @default.
• W1622904595 hasConceptScore W1622904595C2779234561 @default.
• W1622904595 hasConceptScore W1622904595C2779441745 @default.
• W1622904595 hasConceptScore W1622904595C2780186607 @default.
• W1622904595 hasConceptScore W1622904595C2781039349 @default.
• W1622904595 hasConceptScore W1622904595C2908647359 @default.
• W1622904595 hasConceptScore W1622904595C2986740045 @default.
• W1622904595 hasConceptScore W1622904595C2986817661 @default.
• W1622904595 hasConceptScore W1622904595C530470458 @default.
• W1622904595 hasConceptScore W1622904595C54355233 @default.
• W1622904595 hasConceptScore W1622904595C71924100 @default.
• W1622904595 hasConceptScore W1622904595C86803240 @default.
• W1622904595 hasConceptScore W1622904595C99454951 @default.
• W1622904595 hasIssue "S4" @default.
• W1622904595 hasLocation W16229045951 @default.
• W1622904595 hasLocation W16229045952 @default.
• W1622904595 hasOpenAccess W1622904595 @default.
• W1622904595 hasPrimaryLocation W16229045951 @default.
• W1622904595 hasRelatedWork W2008329556 @default.
• W1622904595 hasRelatedWork W2032238979 @default.
• W1622904595 hasRelatedWork W2050558447 @default.
• W1622904595 hasRelatedWork W2156903058 @default.
• W1622904595 hasRelatedWork W2464204462 @default.
• W1622904595 hasRelatedWork W4250301531 @default.
• W1622904595 hasRelatedWork W4251103952 @default.
• W1622904595 hasRelatedWork W2186428359 @default.
• W1622904595 hasRelatedWork W2219551112 @default.
• W1622904595 hasRelatedWork W2295787541 @default.
• W1622904595 hasVolume "71" @default.
• W1622904595 isParatext "false" @default.
• W1622904595 isRetracted "false" @default.
• W1622904595 magId "1622904595" @default.

• next