Matches in SemOpenAlex for { <https://semopenalex.org/work/W162292669> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W162292669 endingPage "26" @default.
- W162292669 startingPage "814" @default.
- W162292669 abstract "Thalidomide and analogues are a class of immunomodulatory drugs or IMiDS. Thalidomide was initially approved by the U.S. Food and Drug Administation for treatment of erythema nodosum in leprosy and is now approved for multiple myeloma as well. A second generation IMiD, lenalidomide, is also approved for multiple myeloma and refractory myelodysplastic syndrome. Discovery of this class of drugs has been serendipitous and empirical, as the drug targets have been unknown. In this review, the authors integrate recent identification of drug targets of IMiDS, which include the inducible form of nitric oxide synthase (iNOS), Rho GTPase and caspase-1, with the developments in the understanding of the molecular biology of human inflammatory, infectious and neoplastic skin disorders. Because thalidomide reemerged through leprosy, the original disease classified by the T cell, the authors have also emphasized advances in the understanding of T-cell subsets in human skin disorders." @default.
- W162292669 created "2016-06-24" @default.
- W162292669 creator A5012680934 @default.
- W162292669 creator A5018250524 @default.
- W162292669 creator A5022124911 @default.
- W162292669 creator A5050812473 @default.
- W162292669 date "2010-07-01" @default.
- W162292669 modified "2023-09-23" @default.
- W162292669 title "Thalidomide and analogues: potential for immunomodulation of inflammatory and neoplastic dermatologic disorders." @default.
- W162292669 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20677538" @default.
- W162292669 hasPublicationYear "2010" @default.
- W162292669 type Work @default.
- W162292669 sameAs 162292669 @default.
- W162292669 citedByCount "3" @default.
- W162292669 countsByYear W1622926692016 @default.
- W162292669 countsByYear W1622926692021 @default.
- W162292669 crossrefType "journal-article" @default.
- W162292669 hasAuthorship W162292669A5012680934 @default.
- W162292669 hasAuthorship W162292669A5018250524 @default.
- W162292669 hasAuthorship W162292669A5022124911 @default.
- W162292669 hasAuthorship W162292669A5050812473 @default.
- W162292669 hasConcept C16005928 @default.
- W162292669 hasConcept C203014093 @default.
- W162292669 hasConcept C2776063141 @default.
- W162292669 hasConcept C2776364478 @default.
- W162292669 hasConcept C2777478702 @default.
- W162292669 hasConcept C2779609412 @default.
- W162292669 hasConcept C2780035454 @default.
- W162292669 hasConcept C71924100 @default.
- W162292669 hasConcept C98274493 @default.
- W162292669 hasConceptScore W162292669C16005928 @default.
- W162292669 hasConceptScore W162292669C203014093 @default.
- W162292669 hasConceptScore W162292669C2776063141 @default.
- W162292669 hasConceptScore W162292669C2776364478 @default.
- W162292669 hasConceptScore W162292669C2777478702 @default.
- W162292669 hasConceptScore W162292669C2779609412 @default.
- W162292669 hasConceptScore W162292669C2780035454 @default.
- W162292669 hasConceptScore W162292669C71924100 @default.
- W162292669 hasConceptScore W162292669C98274493 @default.
- W162292669 hasIssue "7" @default.
- W162292669 hasLocation W1622926691 @default.
- W162292669 hasOpenAccess W162292669 @default.
- W162292669 hasPrimaryLocation W1622926691 @default.
- W162292669 hasRelatedWork W1972721367 @default.
- W162292669 hasRelatedWork W1977865587 @default.
- W162292669 hasRelatedWork W1985187185 @default.
- W162292669 hasRelatedWork W2027549256 @default.
- W162292669 hasRelatedWork W2030745433 @default.
- W162292669 hasRelatedWork W2031485194 @default.
- W162292669 hasRelatedWork W2032074003 @default.
- W162292669 hasRelatedWork W2053127979 @default.
- W162292669 hasRelatedWork W2089341205 @default.
- W162292669 hasRelatedWork W2094591634 @default.
- W162292669 hasRelatedWork W2100578865 @default.
- W162292669 hasRelatedWork W2145216861 @default.
- W162292669 hasRelatedWork W2156402178 @default.
- W162292669 hasRelatedWork W2167736322 @default.
- W162292669 hasRelatedWork W2332395601 @default.
- W162292669 hasRelatedWork W2397551425 @default.
- W162292669 hasRelatedWork W2593117122 @default.
- W162292669 hasRelatedWork W2758930873 @default.
- W162292669 hasRelatedWork W95480372 @default.
- W162292669 hasRelatedWork W173928540 @default.
- W162292669 hasVolume "9" @default.
- W162292669 isParatext "false" @default.
- W162292669 isRetracted "false" @default.
- W162292669 magId "162292669" @default.
- W162292669 workType "article" @default.